Persistence at one year of age of antigen-induced cellular immune responses in preterm infants vaccinated against whooping cough: Comparison of three different vaccines and effect of a booster dose

• Published in: Vaccine 2013-04, Vol.31 (15), p.1981-1986
• Main Authors: Vermeulen, Françoise, Dirix, Violette, Verscheure, Virginie, Damis, Eliane, Vermeylen, Danièle, Locht, Camille, Mascart, Françoise
• Format: Article
• Language: English
• Subjects: Age; Allergy and Immunology; antigens; Antigens, Bacterial - immunology; Applied microbiology; Bacterial diseases; Belgium; Biological and medical sciences; Bordetella pertussis; cell-mediated immunity; children; Cytokines; Diphtheria-Tetanus-Pertussis Vaccine - administration & dosage; Diphtheria-Tetanus-Pertussis Vaccine - immunology; Ent and stomatologic bacterial diseases; Female; Fundamental and applied biological sciences. Psychology; Haemophilus Vaccines - administration & dosage; Haemophilus Vaccines - immunology; Hepatitis B Vaccines - administration & dosage; Hepatitis B Vaccines - immunology; Human bacterial diseases; Humans; Immune response; Immune system; Immunity, Cellular - immunology; Immunization, Secondary; infancy; Infant; Infant, Newborn; Infant, Premature - immunology; Infant, Premature, Diseases - immunology; Infant, Premature, Diseases - prevention & control; Infants; Infectious diseases; Interferon-gamma; Interferon-gamma - immunology; Interleukin-5; Interleukin-5 - immunology; Male; Medical sciences; Microbiology; Pertussis Vaccine - administration & dosage; Pertussis Vaccine - immunology; Pertussis vaccines; Poliovirus Vaccine, Inactivated - administration & dosage; Poliovirus Vaccine, Inactivated - immunology; Premature birth; Preterm infants; risk; Studies; Time Factors; Vaccination; Vaccines; Vaccines, Acellular - administration & dosage; Vaccines, Acellular - immunology; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Vaccines, Combined - administration & dosage; Vaccines, Combined - immunology; Whooping cough; Whooping Cough - immunology; Whooping Cough - prevention & control
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2013.02.004

Highlights ► Persistence of B. pertussis cellular immune responses in vaccinated premature infants. ► No effect of a 1 year vaccine booster on the B. pertussis cellular immune response. ► Low B. pertussis IFN-γ/IL-5 ratio induced by acellular vaccines.