Identification of two paralogous caprine CD36 genes that display highly divergent mRNA expression profiles

Abstract The CD36 molecule plays a pivotal role in a variety of immunological and cellular processes, including pathogen recognition, inflammation and apoptosis. Herein, we demonstrate that this gene is duplicated in goats, with two copies ( CD36 and CD36-like ) that display highly divergent mRNA ex...

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Bibliographic Details
Published in:Comparative immunology, microbiology and infectious diseases microbiology and infectious diseases, 2013-01, Vol.36 (1), p.1-7
Main Authors: Zidi, A, Castelló, A, Jordana, J, Carrizosa, J, Urrutia, B, Serradilla, J.M, Amills, M
Format: Article
Language:English
Subjects:
Adipose tissue
Alleles
Allergy and Immunology
Amino Acid Sequence
Animals
Biological and medical sciences
CD36 Antigens - chemistry
CD36 Antigens - genetics
CD36 Antigens - metabolism
CD36 gene
Female
Fundamental and applied biological sciences. Psychology
Gene duplication
Gene Expression Profiling
Gene Frequency
Genetic Loci
Genome
Genotype
Goat
Goats - genetics
Goats - metabolism
Infectious Disease
Microbiology
Milk - cytology
Phylogeny
Polymorphism, Genetic
RNA, Messenger - metabolism
Ruminantia
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Summary:Abstract The CD36 molecule plays a pivotal role in a variety of immunological and cellular processes, including pathogen recognition, inflammation and apoptosis. Herein, we demonstrate that this gene is duplicated in goats, with two copies ( CD36 and CD36-like ) that display highly divergent mRNA expression profiles. In this way, CD36 mRNA is mostly expressed in the adipose tissue and heart whilst CD36-like mRNA shows a high expression in the liver. We have also found evidence of the presence of two paralogous CD36 and CD36-like genes in the bovine genome, suggesting that CD36 duplication took place before goat–cattle radiation, i.e. at least 20 MYR ago. Finally, we have characterized the polymorphism of the coding regions of the goat CD36 and CD36-like genes. In doing so, we have identified one synonymous polymorphism at the CD36-like gene (c.390A>C) that displays a significant association ( P = 0.04) with milk somatic cell count, a parameter often used to diagnose mastitis in domestic ruminants.
ISSN:0147-9571
1878-1667
DOI:10.1016/j.cimid.2012.08.003