PET/CT mediastinal and liver FDG uptake: Effects of biological and procedural factors

Introduction To establish the effects of biological and procedural factors on mediastinal and liver [18F]‐fluorodeoxyglucose (FDG) uptake in oncological FDG positron emission tomography/computed tomography (PET/CT). Methods This retrospective study included 557 patients who had a baseline FDG PET/CT...

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Bibliographic Details
Published in:Journal of medical imaging and radiation oncology 2013-04, Vol.57 (2), p.169-175
Main Authors: Malladi, Ashish, Viner, Maya, Jackson, Tatianie, Mercier, Gustavo, Subramaniam, Rathan M
Format: Article
Language:English
Subjects:
Age Distribution
Aging - metabolism
Body Mass Index
Boston - epidemiology
Diabetes
FDG
Female
Fluorodeoxyglucose F18 - pharmacokinetics
Glucose
Humans
incubation
intravenous contrast
Liver
Liver Neoplasms - diagnosis
Liver Neoplasms - epidemiology
Liver Neoplasms - metabolism
Male
Mediastinal Neoplasms - diagnosis
Mediastinal Neoplasms - epidemiology
Mediastinal Neoplasms - metabolism
Metabolic Clearance Rate
Middle Aged
Multimodal Imaging - statistics & numerical data
Organ Specificity
quantitation
Radiopharmaceuticals - pharmacokinetics
Regression analysis
Reproducibility of Results
Sensitivity and Specificity
Sex Distribution
standardised uptake value
Studies
Tissue Distribution
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Summary:Introduction To establish the effects of biological and procedural factors on mediastinal and liver [18F]‐fluorodeoxyglucose (FDG) uptake in oncological FDG positron emission tomography/computed tomography (PET/CT). Methods This retrospective study included 557 patients who had a baseline FDG PET/CT scan in 2008 and 2009. Mediastinal and liver standardised uptake values mean normalised to lean body mass (SUVlbmmean) were measured in each patient. Univariate and multivariate regression models were established. Study population was then dichotomised into low and high body mass index (BMI) groups, and linear regression models were established for the effects of age, incubation period and blood glucose levels. Results BMI had the highest adjusted effect (standardised beta coefficient, b = 0.43) (P 
ISSN:1754-9477
1754-9485
DOI:10.1111/1754-9485.12015