Assessment of Brain Metabolites Change during Visual Sexual Stimulation in Healthy Women Using Functional MR Spectroscopy

Numerous functional magnetic resonance imaging (fMRI) studies demonstrated the key brain areas associated with visual sexual arousal. However, the changes in brain metabolites involved in sexual stimuli have not been reported. This study utilized functional MR spectroscopy (fMRS) to evaluate the cha...

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Bibliographic Details
Published in:Journal of sexual medicine 2013-04, Vol.10 (4), p.1001-1011
Main Authors: Kim, Tae‐Hoon, Kang, Heoung‐Keun, Jeong, Gwang‐Woo
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Aspartic Acid - analogs & derivatives
Aspartic Acid - metabolism
Brain - metabolism
Brain Centers Associated with Sexual Arousal
Brain Mapping
Brain Metabolites
Choline - metabolism
Creatine - metabolism
Erotica
Female
Functional Magnetic Resonance Imaging (fMRI)
Functional Magnetic Resonance Spectroscopy (fMRS)
Glutamic Acid - metabolism
Glutamine - metabolism
Humans
Inositol - metabolism
Lactic Acid - metabolism
Libido
Lipid Metabolism
Magnetic Resonance Spectroscopy
Middle Aged
Photic Stimulation
Sexual Arousal
Sexual Behavior
Visual Stimulation
Young Adult
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Summary:Numerous functional magnetic resonance imaging (fMRI) studies demonstrated the key brain areas associated with visual sexual arousal. However, the changes in brain metabolites involved in sexual stimuli have not been reported. This study utilized functional MR spectroscopy (fMRS) to evaluate the changes in brain metabolites associated with sexual arousal induced by stimulation with erotic video clips in healthy women. Twenty‐three healthy, right‐handed women (38.4 ± 10.0 years) participated in 1H‐fMRS and fMRI studies. T1 and T2 MR images were used for voxel localization of the anterior cingulate gyrus, which is one of the most important key centers associated with sexual arousal. The changes of brain metabolites were measured using 1H‐fMRS during time‐course activation: “before,” “during,” and “after” visual sexual stimulation. The time‐course variation of the brain metabolites was analyzed by the repeated‐measures analysis of variance. The CVmean of all the metabolites had
ISSN:1743-6095
1743-6109
DOI:10.1111/jsm.12057