Novel Inflammatory Marker in Dialysis Patients: YKL-40

• Published in: Therapeutic apheresis and dialysis 2013-04, Vol.17 (2), p.193-201
• Main Authors: Okyay, Gülay Ulusal, Er, Ramazan Erdem, Tekbudak, Merve Yasemin, Paşaoğlu, Özge, İnal, Salih, Öneç, Kürşad, Paşaoğlu, Hatice, Altok, Kadriye, Derici, Ülver, Erten, Yasemin
• Format: Article
• Language: English
• Subjects: Adipokines - blood; Adult; C-Reactive Protein - metabolism; Case-Control Studies; Chitinase-3-Like Protein 1; Cholesterol, HDL - blood; Chronic renal failure; Creatinine - blood; Cross-Sectional Studies; Dialysis; Female; Hemoglobins - metabolism; Humans; Inflammation; Inflammation - pathology; Interleukin-6 - blood; Kidney Failure, Chronic - therapy; Lectins - blood; Male; Middle Aged; Multivariate Analysis; Peritoneal Dialysis; Regression Analysis; Renal Dialysis; Serum Albumin - metabolism; YKL-40
• ISSN: 1744-9979; 1744-9987
• DOI: 10.1111/j.1744-9987.2012.01141.x

YKL‐40 has been introduced as a marker of inflammation in different clinical situations. The association between YKL‐40 and inflammation in chronic renal failure patients has not been researched currently. The objectives of this study were to establish serum YKL‐40 concentrations in dialysis patients with chronic renal failure compared to healthy subjects and to explore its relationships with a proinflammatory cytokine, interleukine‐6 (IL‐6) and an acute phase mediator, high sensitivity C‐reactive protein (hs‐CRP). The study population included hemodialysis patients (N = 43; mean age of 40.9 ± 14.5), peritoneal dialysis patients (N = 38; mean age of 45.8 ± 13.7) and healthy subjects (N = 37; mean age of 45.5 ± 10.6). Serum concentrations of YKL‐40, IL‐6, hs‐CRP and routine laboratory measures were evaluated. Compared to the healthy subjects, hemodialysis and peritoneal dialysis patients had higher concentrations of YKL‐40, IL‐6, hs‐CRP, as well as lower concentrations of hemoglobin, serum albumin and high density lipoprotein‐cholesterol (P