Expression of MAGE A1-6 and the clinical characteristics of papillary thyroid carcinoma

The expression of melanoma-associated antigen (MAGE) gene has been studied in many types of cancer. In the present study we evaluated the correlation between MAGE expression and the clinical features and oncologic outcomes of patients with papillary thyroid cancer (PTC). We performed a retrospective...

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Bibliographic Details
Published in:Anticancer research 2013-04, Vol.33 (4), p.1731-1735
Main Authors: Lee, Hyoung Shin, Kim, Sung Won, Hong, Jong Chul, Jung, Sang Bong, Jeon, Chang-Ho, Park, Jong Wook, Park, Sung Young, Lee, Kang Dae
Format: Article
Language:English
Subjects:
Adult
Aged
Antigens, Neoplasm - genetics
Biomarkers, Tumor - genetics
Carcinoma, Papillary - genetics
Carcinoma, Papillary - mortality
Carcinoma, Papillary - pathology
Female
Follow-Up Studies
Humans
Lymphatic Metastasis
Male
Melanoma-Specific Antigens - genetics
Middle Aged
Neoplasm Proteins - genetics
Neoplasm Recurrence, Local - genetics
Neoplasm Recurrence, Local - mortality
Neoplasm Recurrence, Local - pathology
Neoplasm Staging
Polymerase Chain Reaction
Prognosis
Retrospective Studies
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - genetics
Survival Rate
Thyroid Neoplasms - genetics
Thyroid Neoplasms - mortality
Thyroid Neoplasms - pathology
Young Adult
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Summary:The expression of melanoma-associated antigen (MAGE) gene has been studied in many types of cancer. In the present study we evaluated the correlation between MAGE expression and the clinical features and oncologic outcomes of patients with papillary thyroid cancer (PTC). We performed a retrospective review of 85 patients who underwent surgery for PTC and analysis of their tumor tissue by nested reverse transcription-polymerase chain reaction (RT-PCR) with the MAGE common primer to detect the MAGE A1-6 gene. The associations between MAGE expression and clinical characteristics were analyzed. Expression of MAGE A1-6 in PTC was identified in 31 patients (36.5%). Only papillary thyroid microcarcinoma (PTMC) was significantly related to MAGE expression in our univariate analysis (p=0.002) and multivariate analysis (p=0.006). MAGE had no significant impact on survival. Expression of MAGE A1-6 in PTC is significantly correlated with the presence of PTMC. Our study suggests that MAGE expression may be related to early-stage PTC.
ISSN:1791-7530