Lipoleiomyosarcoma of the larynx

Background Lipoleiomyosarcoma is a rare tumor consisting of well‐differentiated liposarcoma and leiomyosarcoma. The ear–nose–throat location of lipoleiomyosarcoma has not been previously described. Methods and Results A 37‐year‐old man with a dysphagia had a dyspnea after an endoscopy. A large tumor...

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Bibliographic Details
Published in:Head & neck 2013-05, Vol.35 (5), p.E164-E166
Main Authors: Trijolet, J. P., Lescanne, E., Morinière, S., Robier, A., Bakhos, D., Irish, Jonathan
Format: Article
Language:English
Subjects:
Adult
CDK4
Cyclin-Dependent Kinase 4 - metabolism
Humans
Immunohistochemistry
Laryngeal Neoplasms - metabolism
Laryngeal Neoplasms - pathology
Laryngeal Neoplasms - surgery
larynx
Leiomyosarcoma - metabolism
Leiomyosarcoma - pathology
Leiomyosarcoma - surgery
lipoleiomyosarcoma
Liposarcoma - metabolism
Liposarcoma - pathology
Liposarcoma - surgery
Male
MDM2
Nucleic Acid Amplification Techniques
Proto-Oncogene Proteins c-mdm2 - metabolism
soft tissue tumors
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Summary:Background Lipoleiomyosarcoma is a rare tumor consisting of well‐differentiated liposarcoma and leiomyosarcoma. The ear–nose–throat location of lipoleiomyosarcoma has not been previously described. Methods and Results A 37‐year‐old man with a dysphagia had a dyspnea after an endoscopy. A large tumor was exteriorized from the man's mouth. The lesion was pedicled to the epiglottis. A histologic examination determined that the tumor was a lipoleiomyosarcoma. MDM2 and CDK4 gene amplification were positive. Due to the risk of recurrence, a second intervention was performed to complete the excision. Conclusion These tumors develop in cavities slowly and gradually. The treatment of this lesion is surgical with a sufficient resection margin. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.22905