Reduced Serum Nerve Growth Factor in Patients With Late-Life Depression

Introduction Nerve growth factor (NGF) is one of the most abundant neurotrophic factors in the central nervous system and has been involved in several neuropsychiatric disorders. Methods We recruited 77 age- and gender-matched elderly subjects (38 with late-life depression, 17 with previous major de...

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Published in:The American journal of geriatric psychiatry 2013-05, Vol.21 (5), p.493-496
Main Authors: Diniz, Breno S., M.D., Ph.D, Teixeira, Antonio L., M.D., Ph.D, Machado-Vieira, Rodrigo, M.D., Ph.D, Talib, Leda L., Ph.D, Gattaz, Wagner F., M.D., Ph.D, Forlenza, Orestes V., M.D., Ph.D
Format: Article
Language:English
Subjects:
Aged
Aging - blood
Aging - metabolism
Biomarkers - blood
Case-Control Studies
Depressive Disorder, Major - blood
Female
Humans
Internal Medicine
Male
Middle Aged
Nerve Growth Factor - blood
Remission Induction
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Summary:Introduction Nerve growth factor (NGF) is one of the most abundant neurotrophic factors in the central nervous system and has been involved in several neuropsychiatric disorders. Methods We recruited 77 age- and gender-matched elderly subjects (38 with late-life depression, 17 with previous major depressive episode, and 22 healthy subjects in the comparison group). Serum concentration of NGF was determined by enzyme-linked immunosorbent assay. Results NGF levels were significantly reduced in the depressed patients (p = 0.002) as compared with healthy elderly controls. Elderly control subjects with previous depressive episode also showed a significant reduction in NGF levels as compared with controls (p 
ISSN:1064-7481
1545-7214
DOI:10.1016/j.jagp.2013.01.014