The influence of propofol, remifentanil and lidocaine on the tone of human bronchial smooth muscle

Abstract Background Bronchoscopy is generally a safe procedure, but the induction of anaesthesia can induce bronchospasm. Consequently we investigated the influence of propofol, remifentanil and lidocaine on the tone of the human bronchial smooth muscle. Materials and methods The influence of propof...

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Bibliographic Details
Published in:Pulmonary pharmacology & therapeutics 2013-06, Vol.26 (3), p.325-331
Main Authors: Rogliani, Paola, Calzetta, Luigino, Rendina, Erino A, Massullo, Domenico, Dauri, Mario, Rinaldi, Barbara, Capuano, Annalisa, Matera, Maria Gabriella
Format: Article
Language:English
Subjects:
Bronchi - drug effects
Bronchial hyperresponsiveness
Bronchial Spasm - physiopathology
Bronchoscopy
Electric Stimulation
Female
Human isolated airways
Humans
Hypnotics and Sedatives - pharmacology
In Vitro Techniques
Lidocaine
Lidocaine - pharmacology
Male
Medical Education
Middle Aged
Muscle Contraction - drug effects
Muscle, Smooth - drug effects
Nitric Oxide Synthase - metabolism
Piperidines - pharmacology
Propofol
Propofol - pharmacology
Pulmonary/Respiratory
Remifentanil
Sensory Receptor Cells - metabolism
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Summary:Abstract Background Bronchoscopy is generally a safe procedure, but the induction of anaesthesia can induce bronchospasm. Consequently we investigated the influence of propofol, remifentanil and lidocaine on the tone of the human bronchial smooth muscle. Materials and methods The influence of propofol, remifentanil and lidocaine on the contractile response of human bronchial smooth muscle to electrical field stimulation (EFS) has been evaluated. The role of capsaicin-sensitive sensory nerves and of inducible nitric oxide synthase has also been assessed. Furthermore, the interaction between these three dugs has been measured by Bliss Independence (BI) theory. Statistical significance ( P  
ISSN:1094-5539
1522-9629
DOI:10.1016/j.pupt.2013.01.002