Preoperative Prediction of Growth Hormone (GH)/Insulin-Like Growth Factor-1 (IGF-1) Axis Modification and Postoperative Changes in Candidates for Bariatric Surgery

Background Several factors alter the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis in obese patients, but GH/IGF-1 correlation with anthropometric parameters and lipid metabolism is still unclear. We evaluated this relationship and the postoperative axis modifications in candidates f...

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Bibliographic Details
Published in:Obesity surgery 2013-05, Vol.23 (5), p.594-601
Main Authors: Mittempergher, Francesco, Pata, Giacomo, Crea, Nicola, Di Betta, Ernesto, Vilardi, Antonio, Chiesa, Deborah, Nascimbeni, Riccardo
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biomarkers - blood
Body Mass Index
Cholesterol - blood
Female
Follow-Up Studies
Gastrointestinal surgery
Gastroplasty - statistics & numerical data
Growth hormones
Homeodomain Proteins - blood
Human Growth Hormone - blood
Humans
Insulin-Like Growth Factor I - metabolism
Insulin-like growth factors
Italy - epidemiology
Lipids
Male
Medicine
Medicine & Public Health
Metabolism
Middle Aged
Obesity
Obesity, Morbid - blood
Obesity, Morbid - epidemiology
Obesity, Morbid - surgery
Original Contributions
Patient Selection
Postoperative Period
Predictive Value of Tests
Preoperative Period
Prospective Studies
Surgery
Transcription Factors - blood
Triglycerides - blood
Weight Loss
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Summary:Background Several factors alter the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis in obese patients, but GH/IGF-1 correlation with anthropometric parameters and lipid metabolism is still unclear. We evaluated this relationship and the postoperative axis modifications in candidates for bariatric surgery. Methods Eighty-eight patients (males/females (M/F), 34/54) scheduled for bariatric surgery (biliopancreatic diversion or laparoscopic-adjustable gastric banding) between 2008 and 2010 were included in this observational, open, prospective study. Results Preoperative serum GH concentrations were found near the lowest limit of normal range in both sexes, with males showing the lowest values (130 vs. 1,405 pg/ml; p  
ISSN:0960-8923
1708-0428
DOI:10.1007/s11695-012-0820-z