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Preoperative Prediction of Growth Hormone (GH)/Insulin-Like Growth Factor-1 (IGF-1) Axis Modification and Postoperative Changes in Candidates for Bariatric Surgery
Background Several factors alter the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis in obese patients, but GH/IGF-1 correlation with anthropometric parameters and lipid metabolism is still unclear. We evaluated this relationship and the postoperative axis modifications in candidates f...
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| Published in: | Obesity surgery 2013-05, Vol.23 (5), p.594-601 |
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| container_title | Obesity surgery |
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| creator | Mittempergher, Francesco Pata, Giacomo Crea, Nicola Di Betta, Ernesto Vilardi, Antonio Chiesa, Deborah Nascimbeni, Riccardo |
| description | Background
Several factors alter the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis in obese patients, but GH/IGF-1 correlation with anthropometric parameters and lipid metabolism is still unclear. We evaluated this relationship and the postoperative axis modifications in candidates for bariatric surgery.
Methods
Eighty-eight patients (males/females (M/F), 34/54) scheduled for bariatric surgery (biliopancreatic diversion or laparoscopic-adjustable gastric banding) between 2008 and 2010 were included in this observational, open, prospective study.
Results
Preoperative serum GH concentrations were found near the lowest limit of normal range in both sexes, with males showing the lowest values (130 vs. 1,405 pg/ml;
p
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| doi_str_mv | 10.1007/s11695-012-0820-z |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1326725444</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2942978121</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-4bf0c2edd016210341b0f457e067664b1b13344785cb12b100bb55645b04e04f3</originalsourceid><addsrcrecordid>eNp1kctuUzEQhi0EoqHwAGyQJTbpwnR8OccnyxKRixREJWBt2T4-rUtiB9sHaF-HF8VtWkBIrEaj-eafy4_QSwpvKIA8zZS2s4YAZQQ6BuTmEZpQCR0BwbrHaAKzFkg3Y_wIPcv5CoDRlrGn6IhxKmdMiAn6eZ5c3Luki__mcE16b4uPAccBL1P8Xi7xKqZdDA5Pl6uT03XI49YHsvFf3AOw0LbERCierpcLQk_w2Q-f8fvY-8FbfaemQ4_PYy5_Rs0vdbhwGfuA57Xqe11qNsSE3-rkdUne4o9junDp-jl6Muhtdi_u4zH6vHj3ab4imw_L9fxsQyyXrBBhBrDM9T3UKylwQQ0MopEOWtm2wlBDORdCdo01lJn6QWOaphWNAeFADPwYTQ-6-xS_ji4XtfPZuu1WBxfHrChnrWSNEKKir_9Br-KYQt3ujuKskaKtFD1QNsWckxvUPvmdTteKgrp1UB0cVNVBdeuguqk9r-6VR7Nz_e-OB8sqwA5ArqX6wvTX6P-q_gJ9iKWn</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1326325746</pqid></control><display><type>article</type><title>Preoperative Prediction of Growth Hormone (GH)/Insulin-Like Growth Factor-1 (IGF-1) Axis Modification and Postoperative Changes in Candidates for Bariatric Surgery</title><source>Springer Nature</source><creator>Mittempergher, Francesco ; Pata, Giacomo ; Crea, Nicola ; Di Betta, Ernesto ; Vilardi, Antonio ; Chiesa, Deborah ; Nascimbeni, Riccardo</creator><creatorcontrib>Mittempergher, Francesco ; Pata, Giacomo ; Crea, Nicola ; Di Betta, Ernesto ; Vilardi, Antonio ; Chiesa, Deborah ; Nascimbeni, Riccardo</creatorcontrib><description>Background
Several factors alter the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis in obese patients, but GH/IGF-1 correlation with anthropometric parameters and lipid metabolism is still unclear. We evaluated this relationship and the postoperative axis modifications in candidates for bariatric surgery.
Methods
Eighty-eight patients (males/females (M/F), 34/54) scheduled for bariatric surgery (biliopancreatic diversion or laparoscopic-adjustable gastric banding) between 2008 and 2010 were included in this observational, open, prospective study.
Results
Preoperative serum GH concentrations were found near the lowest limit of normal range in both sexes, with males showing the lowest values (130 vs. 1,405 pg/ml;
p
< 0.01). Serum concentrations of IGF-1 were within the normal range (M/F, 179/168.5 ng/ml), whereas IGF-binding protein (BP)1 and 3 values were at the lowest limits of normal range in both sexes (M/F 1.8/3.1 μg/ml and M/F 4.1/4.2 μg/ml, respectively). A statistically significant inverse correlation was found between GH, IGF-1, and IGF-BP1-3 values and total cholesterol, LDL-cholesterol, and triglycerides values in both sexes. GH and IGF-BP1-3 values were also inversely related to waist circumference and waist/hip ratio (WHR). GH, IGF-1, and IGF-BP1 and 3 values (35 cases) increased 1 year postoperatively in both sexes, mainly after malabsorptive procedures.
Conclusions
Our results support the hypothesis that GH deficiency associated with low levels of binding proteins in obese patients may be an endocrine response to visceral fat and high levels of non-esterified fatty acids, assessable in daily clinical practice by WHR, total and LDL-cholesterol, and triglycerides. In these patients, malabsorptive procedures might be the treatment of choice due to the metabolic adaptations induced.</description><identifier>ISSN: 0960-8923</identifier><identifier>EISSN: 1708-0428</identifier><identifier>DOI: 10.1007/s11695-012-0820-z</identifier><identifier>PMID: 23179244</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Adolescent ; Adult ; Biomarkers - blood ; Body Mass Index ; Cholesterol - blood ; Female ; Follow-Up Studies ; Gastrointestinal surgery ; Gastroplasty - statistics & numerical data ; Growth hormones ; Homeodomain Proteins - blood ; Human Growth Hormone - blood ; Humans ; Insulin-Like Growth Factor I - metabolism ; Insulin-like growth factors ; Italy - epidemiology ; Lipids ; Male ; Medicine ; Medicine & Public Health ; Metabolism ; Middle Aged ; Obesity ; Obesity, Morbid - blood ; Obesity, Morbid - epidemiology ; Obesity, Morbid - surgery ; Original Contributions ; Patient Selection ; Postoperative Period ; Predictive Value of Tests ; Preoperative Period ; Prospective Studies ; Surgery ; Transcription Factors - blood ; Triglycerides - blood ; Weight Loss</subject><ispartof>Obesity surgery, 2013-05, Vol.23 (5), p.594-601</ispartof><rights>Springer Science+Business Media New York 2012</rights><rights>Springer Science+Business Media New York 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-4bf0c2edd016210341b0f457e067664b1b13344785cb12b100bb55645b04e04f3</citedby><cites>FETCH-LOGICAL-c372t-4bf0c2edd016210341b0f457e067664b1b13344785cb12b100bb55645b04e04f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23179244$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mittempergher, Francesco</creatorcontrib><creatorcontrib>Pata, Giacomo</creatorcontrib><creatorcontrib>Crea, Nicola</creatorcontrib><creatorcontrib>Di Betta, Ernesto</creatorcontrib><creatorcontrib>Vilardi, Antonio</creatorcontrib><creatorcontrib>Chiesa, Deborah</creatorcontrib><creatorcontrib>Nascimbeni, Riccardo</creatorcontrib><title>Preoperative Prediction of Growth Hormone (GH)/Insulin-Like Growth Factor-1 (IGF-1) Axis Modification and Postoperative Changes in Candidates for Bariatric Surgery</title><title>Obesity surgery</title><addtitle>OBES SURG</addtitle><addtitle>Obes Surg</addtitle><description>Background
Several factors alter the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis in obese patients, but GH/IGF-1 correlation with anthropometric parameters and lipid metabolism is still unclear. We evaluated this relationship and the postoperative axis modifications in candidates for bariatric surgery.
Methods
Eighty-eight patients (males/females (M/F), 34/54) scheduled for bariatric surgery (biliopancreatic diversion or laparoscopic-adjustable gastric banding) between 2008 and 2010 were included in this observational, open, prospective study.
Results
Preoperative serum GH concentrations were found near the lowest limit of normal range in both sexes, with males showing the lowest values (130 vs. 1,405 pg/ml;
p
< 0.01). Serum concentrations of IGF-1 were within the normal range (M/F, 179/168.5 ng/ml), whereas IGF-binding protein (BP)1 and 3 values were at the lowest limits of normal range in both sexes (M/F 1.8/3.1 μg/ml and M/F 4.1/4.2 μg/ml, respectively). A statistically significant inverse correlation was found between GH, IGF-1, and IGF-BP1-3 values and total cholesterol, LDL-cholesterol, and triglycerides values in both sexes. GH and IGF-BP1-3 values were also inversely related to waist circumference and waist/hip ratio (WHR). GH, IGF-1, and IGF-BP1 and 3 values (35 cases) increased 1 year postoperatively in both sexes, mainly after malabsorptive procedures.
Conclusions
Our results support the hypothesis that GH deficiency associated with low levels of binding proteins in obese patients may be an endocrine response to visceral fat and high levels of non-esterified fatty acids, assessable in daily clinical practice by WHR, total and LDL-cholesterol, and triglycerides. In these patients, malabsorptive procedures might be the treatment of choice due to the metabolic adaptations induced.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biomarkers - blood</subject><subject>Body Mass Index</subject><subject>Cholesterol - blood</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastrointestinal surgery</subject><subject>Gastroplasty - statistics & numerical data</subject><subject>Growth hormones</subject><subject>Homeodomain Proteins - blood</subject><subject>Human Growth Hormone - blood</subject><subject>Humans</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Insulin-like growth factors</subject><subject>Italy - epidemiology</subject><subject>Lipids</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity, Morbid - blood</subject><subject>Obesity, Morbid - epidemiology</subject><subject>Obesity, Morbid - surgery</subject><subject>Original Contributions</subject><subject>Patient Selection</subject><subject>Postoperative Period</subject><subject>Predictive Value of Tests</subject><subject>Preoperative Period</subject><subject>Prospective Studies</subject><subject>Surgery</subject><subject>Transcription Factors - blood</subject><subject>Triglycerides - blood</subject><subject>Weight Loss</subject><issn>0960-8923</issn><issn>1708-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp1kctuUzEQhi0EoqHwAGyQJTbpwnR8OccnyxKRixREJWBt2T4-rUtiB9sHaF-HF8VtWkBIrEaj-eafy4_QSwpvKIA8zZS2s4YAZQQ6BuTmEZpQCR0BwbrHaAKzFkg3Y_wIPcv5CoDRlrGn6IhxKmdMiAn6eZ5c3Luki__mcE16b4uPAccBL1P8Xi7xKqZdDA5Pl6uT03XI49YHsvFf3AOw0LbERCierpcLQk_w2Q-f8fvY-8FbfaemQ4_PYy5_Rs0vdbhwGfuA57Xqe11qNsSE3-rkdUne4o9junDp-jl6Muhtdi_u4zH6vHj3ab4imw_L9fxsQyyXrBBhBrDM9T3UKylwQQ0MopEOWtm2wlBDORdCdo01lJn6QWOaphWNAeFADPwYTQ-6-xS_ji4XtfPZuu1WBxfHrChnrWSNEKKir_9Br-KYQt3ujuKskaKtFD1QNsWckxvUPvmdTteKgrp1UB0cVNVBdeuguqk9r-6VR7Nz_e-OB8sqwA5ArqX6wvTX6P-q_gJ9iKWn</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Mittempergher, Francesco</creator><creator>Pata, Giacomo</creator><creator>Crea, Nicola</creator><creator>Di Betta, Ernesto</creator><creator>Vilardi, Antonio</creator><creator>Chiesa, Deborah</creator><creator>Nascimbeni, Riccardo</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20130501</creationdate><title>Preoperative Prediction of Growth Hormone (GH)/Insulin-Like Growth Factor-1 (IGF-1) Axis Modification and Postoperative Changes in Candidates for Bariatric Surgery</title><author>Mittempergher, Francesco ; Pata, Giacomo ; Crea, Nicola ; Di Betta, Ernesto ; Vilardi, Antonio ; Chiesa, Deborah ; Nascimbeni, Riccardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-4bf0c2edd016210341b0f457e067664b1b13344785cb12b100bb55645b04e04f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biomarkers - blood</topic><topic>Body Mass Index</topic><topic>Cholesterol - blood</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastrointestinal surgery</topic><topic>Gastroplasty - statistics & numerical data</topic><topic>Growth hormones</topic><topic>Homeodomain Proteins - blood</topic><topic>Human Growth Hormone - blood</topic><topic>Humans</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Insulin-like growth factors</topic><topic>Italy - epidemiology</topic><topic>Lipids</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity, Morbid - blood</topic><topic>Obesity, Morbid - epidemiology</topic><topic>Obesity, Morbid - surgery</topic><topic>Original Contributions</topic><topic>Patient Selection</topic><topic>Postoperative Period</topic><topic>Predictive Value of Tests</topic><topic>Preoperative Period</topic><topic>Prospective Studies</topic><topic>Surgery</topic><topic>Transcription Factors - blood</topic><topic>Triglycerides - blood</topic><topic>Weight Loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mittempergher, Francesco</creatorcontrib><creatorcontrib>Pata, Giacomo</creatorcontrib><creatorcontrib>Crea, Nicola</creatorcontrib><creatorcontrib>Di Betta, Ernesto</creatorcontrib><creatorcontrib>Vilardi, Antonio</creatorcontrib><creatorcontrib>Chiesa, Deborah</creatorcontrib><creatorcontrib>Nascimbeni, Riccardo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mittempergher, Francesco</au><au>Pata, Giacomo</au><au>Crea, Nicola</au><au>Di Betta, Ernesto</au><au>Vilardi, Antonio</au><au>Chiesa, Deborah</au><au>Nascimbeni, Riccardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preoperative Prediction of Growth Hormone (GH)/Insulin-Like Growth Factor-1 (IGF-1) Axis Modification and Postoperative Changes in Candidates for Bariatric Surgery</atitle><jtitle>Obesity surgery</jtitle><stitle>OBES SURG</stitle><addtitle>Obes Surg</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>23</volume><issue>5</issue><spage>594</spage><epage>601</epage><pages>594-601</pages><issn>0960-8923</issn><eissn>1708-0428</eissn><abstract>Background
Several factors alter the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis in obese patients, but GH/IGF-1 correlation with anthropometric parameters and lipid metabolism is still unclear. We evaluated this relationship and the postoperative axis modifications in candidates for bariatric surgery.
Methods
Eighty-eight patients (males/females (M/F), 34/54) scheduled for bariatric surgery (biliopancreatic diversion or laparoscopic-adjustable gastric banding) between 2008 and 2010 were included in this observational, open, prospective study.
Results
Preoperative serum GH concentrations were found near the lowest limit of normal range in both sexes, with males showing the lowest values (130 vs. 1,405 pg/ml;
p
< 0.01). Serum concentrations of IGF-1 were within the normal range (M/F, 179/168.5 ng/ml), whereas IGF-binding protein (BP)1 and 3 values were at the lowest limits of normal range in both sexes (M/F 1.8/3.1 μg/ml and M/F 4.1/4.2 μg/ml, respectively). A statistically significant inverse correlation was found between GH, IGF-1, and IGF-BP1-3 values and total cholesterol, LDL-cholesterol, and triglycerides values in both sexes. GH and IGF-BP1-3 values were also inversely related to waist circumference and waist/hip ratio (WHR). GH, IGF-1, and IGF-BP1 and 3 values (35 cases) increased 1 year postoperatively in both sexes, mainly after malabsorptive procedures.
Conclusions
Our results support the hypothesis that GH deficiency associated with low levels of binding proteins in obese patients may be an endocrine response to visceral fat and high levels of non-esterified fatty acids, assessable in daily clinical practice by WHR, total and LDL-cholesterol, and triglycerides. In these patients, malabsorptive procedures might be the treatment of choice due to the metabolic adaptations induced.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>23179244</pmid><doi>10.1007/s11695-012-0820-z</doi><tpages>8</tpages></addata></record> |
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| source | Springer Nature |
| subjects | Adolescent Adult Biomarkers - blood Body Mass Index Cholesterol - blood Female Follow-Up Studies Gastrointestinal surgery Gastroplasty - statistics & numerical data Growth hormones Homeodomain Proteins - blood Human Growth Hormone - blood Humans Insulin-Like Growth Factor I - metabolism Insulin-like growth factors Italy - epidemiology Lipids Male Medicine Medicine & Public Health Metabolism Middle Aged Obesity Obesity, Morbid - blood Obesity, Morbid - epidemiology Obesity, Morbid - surgery Original Contributions Patient Selection Postoperative Period Predictive Value of Tests Preoperative Period Prospective Studies Surgery Transcription Factors - blood Triglycerides - blood Weight Loss |
| title | Preoperative Prediction of Growth Hormone (GH)/Insulin-Like Growth Factor-1 (IGF-1) Axis Modification and Postoperative Changes in Candidates for Bariatric Surgery |
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