F-FDG PET/CT-based treatment response evaluation in locally advanced rectal cancer: a prospective validation of long-term outcomes

To prospectively evaluate the usefulness of (18)F-FDG PET/CT) imaging for predicting histopathological response and long-term clinical outcomes in locally advanced rectal cancer (LARC). This prospective study included 38 patients with a confirmed diagnosis of LARC (cT3-4 or cN+) who underwent (18)F-...

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Published in:European journal of nuclear medicine and molecular imaging 2013-05, Vol.40 (5), p.657-667
Main Authors: Calvo, Felipe A, Sole, Claudio V, de la Mata, Dolores, Cabezón, Luis, Gómez-Espí, Marina, Alvarez, Emilio, Madariaga, Paz, Carreras, José L
Format: Article
Language:English
Subjects:
Adult
Aged
Female
Fluorodeoxyglucose F18
Follow-Up Studies
Humans
Male
Middle Aged
Multimodal Imaging
Positron-Emission Tomography
Prognosis
Prospective Studies
Rectal Neoplasms - diagnostic imaging
Rectal Neoplasms - metabolism
Rectal Neoplasms - pathology
Rectal Neoplasms - therapy
Reproducibility of Results
Time Factors
Tomography, X-Ray Computed
Treatment Outcome
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Summary:To prospectively evaluate the usefulness of (18)F-FDG PET/CT) imaging for predicting histopathological response and long-term clinical outcomes in locally advanced rectal cancer (LARC). This prospective study included 38 patients with a confirmed diagnosis of LARC (cT3-4 or cN+) who underwent (18)F-FDG PET/CT before and after neoadjuvant therapy (NAT). Total mesorectal excision was scheduled 6 weeks after NAT and was followed by an expert histopathological analysis of the surgical specimen. Baseline variables and previously identified maximum FDG standardized uptake value (SUVmax) cut-off values before NAT (SUVmaxPRE ≥6) and after NAT (SUVmaxPOST ≥2), and the absolute and percentage reductions from baseline SUVmax (∆SUVmax
ISSN:1619-7089
DOI:10.1007/s00259-013-2341-y