Adipose‐derived mesenchymal stem cells and regenerative medicine

Adipose tissue‐derived mesenchymal stem cells (ADSCs) are multipotent and can differentiate into various cell types, including osteocytes, adipocytes, neural cells, vascular endothelial cells, cardiomyocytes, pancreatic β‐cells, and hepatocytes. Compared with the extraction of other stem cells such...

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Bibliographic Details
Published in:Development, growth & differentiation growth & differentiation, 2013-04, Vol.55 (3), p.309-318
Main Authors: Konno, Masamitsu, Hamabe, Atsushi, Hasegawa, Shinichiro, Ogawa, Hisataka, Fukusumi, Takahito, Nishikawa, Shimpei, Ohta, Katsuya, Kano, Yoshihiro, Ozaki, Miyuki, Noguchi, Yuko, Sakai, Daisuke, Kudoh, Toshihiro, Kawamoto, Koichi, Eguchi, Hidetoshi, Satoh, Taroh, Tanemura, Masahiro, Nagano, Hiroaki, Doki, Yuichiro, Mori, Masaki, Ishii, Hideshi
Format: Article
Language:English
Subjects:
Adipose Tissue - cytology
Adipose tissue‐derived mesenchymal stem cells
Animals
Bone marrow
Bone Marrow Cells - cytology
Humans
Mesenchymal Stromal Cells - cytology
multipotency
regenerative medicine
Regenerative Medicine - methods
Stem cells
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Summary:Adipose tissue‐derived mesenchymal stem cells (ADSCs) are multipotent and can differentiate into various cell types, including osteocytes, adipocytes, neural cells, vascular endothelial cells, cardiomyocytes, pancreatic β‐cells, and hepatocytes. Compared with the extraction of other stem cells such as bone marrow‐derived mesenchymal stem cells (BMSCs), that of ADSCs requires minimally invasive techniques. In the field of regenerative medicine, the use of autologous cells is preferable to embryonic stem cells or induced pluripotent stem cells. Therefore, ADSCs are a useful resource for drug screening and regenerative medicine. Here we present the methods and mechanisms underlying the induction of multilineage cells from ADSCs.
ISSN:0012-1592
1440-169X
DOI:10.1111/dgd.12049