Developments in microarray technologies

The focus of high-throughput drug discovery has progressed through the genome and the transcriptome and is now moving towards more difficult problems in assessing the proteome, glycome and metabolome. Microarrays are currently the major tool in the assessment of gene expression via cDNA or RNA analy...

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Bibliographic Details
Published in:Drug discovery today 2004-12, Vol.9 (24), p.1-9
Main Authors: HOWBROOK, David N, VAN DER VALK, Anne M, O'SHAUGHNESSY, Meg C, SARKER, Dipak K, BAKER, Simon C, LLOYD, Andrew W
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Gene Expression Profiling
General pharmacology
Humans
Medical sciences
Microarray Analysis - methods
Microfluidic Analytical Techniques - methods
Nanotechnology
Oligonucleotide Array Sequence Analysis - methods
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Protein Array Analysis - methods
Tissue Array Analysis - methods
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Summary:The focus of high-throughput drug discovery has progressed through the genome and the transcriptome and is now moving towards more difficult problems in assessing the proteome, glycome and metabolome. Microarrays are currently the major tool in the assessment of gene expression via cDNA or RNA analysis; however, they are also used to screen libraries of proteins and small molecules. Microarrays have helped to extract more information from smaller sample volumes and enabled the incorporation of low-cost high-throughput assays in the drug discovery process. The technology continues to develop and is being rapidly transferred into more challenging areas, with the potential to further aid and enhance the drug discovery process through the development of, for example, proteomic, glycomic and tissue arrays.
ISSN:1359-6446
1878-5832