Genomic microarrays in the spotlight

Microarray-based comparative genomic hybridization (array-CGH) has emerged as a revolutionary platform, enabling the high-resolution detection of DNA copy number aberrations. In this article we outline the use and limitations of genomic clones, cDNA clones and PCR products as targets for genomic mic...

Full description

Saved in:
Bibliographic Details
Published in:Drug discovery today 2004-12, Vol.9 (24), p.45-52
Main Authors: MANTRIPRAGADA, Kiran K, BUCKLEY, Patrick G, DIAZ DE STAHL, Teresita, DUMANSKI, Jan P
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Comparative Genomic Hybridization
Gene Dosage
General pharmacology
Genetic Variation
Humans
Medical sciences
Oligonucleotide Array Sequence Analysis - methods
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polymerase Chain Reaction
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Microarray-based comparative genomic hybridization (array-CGH) has emerged as a revolutionary platform, enabling the high-resolution detection of DNA copy number aberrations. In this article we outline the use and limitations of genomic clones, cDNA clones and PCR products as targets for genomic microarray construction. Furthermore, the applications and future aspects of these arrays for DNA copy number analysis in research and diagnostics, epigenetic profiling and gene annotation are discussed. These recent developments of genomic microarrays mark only the beginning of a new generation of high-resolution and high-throughput tools for genetic analysis.
ISSN:1359-6446
1878-5832