Sublingual versus vaginal misoprostol for cervical ripening before hysteroscopy: a randomized clinical trial

Purpose To evaluate the efficacy of two routes of misoprostol (sublingual and vaginal) for cervical ripening before hysteroscopy. Methods One hundred and ten perimenopausal women who were referred to a tertiary hospital for surgical hysteroscopy enrolled in this double-blind randomized clinical tria...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2013-05, Vol.287 (5), p.937-940
Main Authors: Tanha, Fateme Davari, Salimi, Shohreh, Ghajarzadeh, Mahsa
Format: Article
Language:English
Subjects:
Administration, Intravaginal
Administration, Sublingual
Adult
Cervix Uteri - drug effects
Clinical trials
Dilatation
Double-Blind Method
Endocrinology
Female
General Gynecology
Gynecology
Hormone replacement therapy
Human Genetics
Humans
Hysteroscopy - adverse effects
Hysteroscopy - methods
Medicine
Medicine & Public Health
Middle Aged
Misoprostol - administration & dosage
Misoprostol - adverse effects
Obstetrics/Perinatology/Midwifery
Oxytocics - administration & dosage
Oxytocics - adverse effects
Perimenopause
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Summary:Purpose To evaluate the efficacy of two routes of misoprostol (sublingual and vaginal) for cervical ripening before hysteroscopy. Methods One hundred and ten perimenopausal women who were referred to a tertiary hospital for surgical hysteroscopy enrolled in this double-blind randomized clinical trial. They were divided into two groups to receive 400 mg misoprostol either sublingually or vaginally 6 h before hysteroscopy. The duration of dilatation, Hegar number inserted into the cervix without resistance, and hysteroscopic and drug complications were recorded for all cases. Results Forty-nine women in sublingual and 51 in vaginal group participated in the study. Dilatation time was significantly lower in sublingual group ( P  
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-012-2652-4