TRPM7 mediates breast cancer cell migration and invasion through the MAPK pathway

Highlights ► TRPM7 overexpression is correlated to cancer metastasis and invasive breast cancers. ► Knockdown of TRPM7 suppresses MDA-MB-435 breast cancer cell migration and invasion. ► TRPM7 mediates migration and invasion of MDA-MB-435 breast cancer cell through the MAPK pathway.

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Bibliographic Details
Published in:Cancer letters 2013-06, Vol.333 (1), p.96-102
Main Authors: Meng, Xiaojing, Cai, Chunqing, Wu, Jiguo, Cai, Shaoxi, Ye, Changsheng, Chen, Haiyang, Yang, Zhengduo, Zeng, Hongqiang, Shen, Qiang, Zou, Fei
Format: Article
Language:English
Subjects:
Breast cancer
breast neoplasms
Breast Neoplasms - pathology
Cell adhesion & migration
Cell Line, Tumor
Cell Movement
Female
Hematology, Oncology and Palliative Medicine
Humans
Invasion
Kinases
MAP Kinase Signaling System - physiology
MAPK
metastasis
Neoplasm Invasiveness
Phosphatidylinositol 3-Kinases - physiology
phosphorylation
Protein-Serine-Threonine Kinases
Proto-Oncogene Proteins c-akt - physiology
RNA interference
RNA, Small Interfering - genetics
Signal transduction
Src
TRPM Cation Channels - physiology
TRPM7
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Description
Summary:Highlights ► TRPM7 overexpression is correlated to cancer metastasis and invasive breast cancers. ► Knockdown of TRPM7 suppresses MDA-MB-435 breast cancer cell migration and invasion. ► TRPM7 mediates migration and invasion of MDA-MB-435 breast cancer cell through the MAPK pathway.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2013.01.031