Detection of circulating tumor cells in different stages of prostate cancer

• Published in: Journal of cancer research and clinical oncology 2013-05, Vol.139 (5), p.755-763
• Main Authors: Thalgott, Mark, Rack, Brigitte, Maurer, Tobias, Souvatzoglou, Michael, Eiber, Matthias, Kreß, Veronika, Heck, Matthias M., Andergassen, Ulrich, Nawroth, Roman, Gschwend, Jürgen E., Retz, Margitta
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Antineoplastic agents; Biological and medical sciences; Biomarkers; Biomarkers, Tumor - blood; Bone Neoplasms - pathology; Bone Neoplasms - secondary; Cancer Research; Cells; Gynecology. Andrology. Obstetrics; Hematology; Humans; Internal Medicine; Male; Male genital diseases; Medical prognosis; Medical sciences; Medicine; Medicine & Public Health; Metastasis; Middle Aged; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Neoplasm Metastasis; Neoplasm Staging; Neoplastic Cells, Circulating; Nephrology. Urinary tract diseases; Oncology; Original Paper; Pharmacology. Drug treatments; Prostate cancer; Prostatic Neoplasms - mortality; Prostatic Neoplasms - pathology; ROC Curve; Tumor Burden; Tumors; Tumors of the urinary system; Urinary tract. Prostate gland
• ISSN: 0171-5216; 1432-1335
• DOI: 10.1007/s00432-013-1377-5

Purpose To explore circulating tumor cell (CTCs) counts in different stages of prostate cancer (PC) in association with tumor burden, metastatic pattern and conventional serum biomarkers. Overall survival (OS) analyses were conducted with respect to optimized CTC cutoff levels. Methods Circulating tumor cell counts were assessed in healthy controls ( n  = 15) as well as in locally advanced high risk (LAPC, n  = 20), metastatic castration resistant (mCRPC, n  = 40) and taxane-refractory (mTRPC, n  = 15) PC patients. CTCs were detected using the CellSearch™ System. Results In metastatic PC (mPC), CTC counts were significantly increased compared to LAPC ( p