Graphene oxide modified PLA microcapsules containing gold nanoparticles for ultrasonic/CT bimodal imaging guided photothermal tumor therapy

Abstract Theranostic microcapsules were successfully fabricated by introducing gold nanoparticles into poly(lactic acid) microcapsules through a double-microemulsion method, followed by depositing graphene oxide onto the microcapsule surface via electrostatic layer-by-layer self-assembly technique....

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Bibliographic Details
Published in:Biomaterials 2013-07, Vol.34 (20), p.4794-4802
Main Authors: Jin, Yushen, Wang, Jinrui, Ke, Hengte, Wang, Shumin, Dai, Zhifei
Format: Article
Language:English
Subjects:
Acoustics
Advanced Basic Science
Animals
Capsules
Cell Survival
Computed tomography
Dentistry
Gold
Graphite - chemistry
HeLa Cells
Human Umbilical Vein Endothelial Cells
Humans
Hyperthermia, Induced
Lactic Acid - chemistry
Metal Nanoparticles - chemistry
Metal Nanoparticles - ultrastructure
Mice
Mice, Nude
Microcapsules
Microscopy, Fluorescence
Neoplasms - diagnostic imaging
Neoplasms - pathology
Neoplasms - therapy
Phantoms, Imaging
Phototherapy
Photothermal therapy
Polyesters
Polymers - chemistry
Rabbits
Spectroscopy, Near-Infrared
Temperature
Theranostic agent
Tomography, X-Ray Computed
Ultrasonics
Ultrasonography
Ultrasound imaging
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Summary:Abstract Theranostic microcapsules were successfully fabricated by introducing gold nanoparticles into poly(lactic acid) microcapsules through a double-microemulsion method, followed by depositing graphene oxide onto the microcapsule surface via electrostatic layer-by-layer self-assembly technique. It was proved that the obtained microcapsules could serve as a contrast agent to simultaneously enhance US imaging and X-ray CT imaging greatly both in vitro and in vivo . In addition, the in vivo therapeutic examinations showed that the microcapsule was an effective agent for photothermal therapy of cancer. The near-infrared laser light ablated the tumor completely within 9 days in the presence of the microcapsules and the tumor growth inhibition was 83.8%. The combination of real-time ultrasound with 3-D computed tomography through a single microcapsule agent is very helpful for accurately interpreting the obtained images, identifying the size and location of the tumor, as well as guiding and monitoring the photothermal therapy. Simultaneously, the effectiveness of photothermal therapy could be evaluated by the combined US and CT imaging enhanced by the microcapsule agent. Such a versatile microcapsule system might bring opportunities to the next generation of multimodal imaging guided cancer therapy.
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2013.03.027