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Prospective, Randomized, Open-Label Trial Comparing the Safety, Efficacy, and Tolerability of an Acne Treatment Regimen with and without a Probiotic Supplement and Minocycline in Subjects with Mild to Moderate Acne
Background: Systemic antibiotics are an effective treatment for acne vulgaris. However, intolerable side effects may invariably occur. Objective: To determine whether probiotics reduce the side effects imparted by systemic antibiotics while working synergistically with the latter in treating inflamm...
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| Published in: | Journal of cutaneous medicine and surgery 2013-03, Vol.17 (2), p.114-122 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c362t-14b54f6c9920a39943f3d4aaf76e44cc06f33d4ff31ac8e867d5937293770cb93 |
| container_end_page | 122 |
| container_issue | 2 |
| container_start_page | 114 |
| container_title | Journal of cutaneous medicine and surgery |
| container_volume | 17 |
| creator | Jung, Gordon W. Tse, Jennifer E. Guiha, Isabella Rao, Jaggi |
| description | Background:
Systemic antibiotics are an effective treatment for acne vulgaris. However, intolerable side effects may invariably occur.
Objective:
To determine whether probiotics reduce the side effects imparted by systemic antibiotics while working synergistically with the latter in treating inflammatory acne.
Methods:
Forty-five 18- to 35-year-old females were randomly assigned to one of three arms in this prospective, open-label study. Group A received probiotic supplementation, whereas group B received only minocycline. Group C was treated with both probiotic and minocycline. Clinical and subjective assessments were completed at baseline and during the 2-, 4-, 8-, and 12-week follow-up visits.
Results:
All patients demonstrated a significant improvement in total lesion count 4 weeks after treatment initiation (p < .001), with continued improvement seen with each subsequent follow-up visit (p < .01). At the 8- and 12-week follow-up visits, group C had a significant decrease in total lesion count versus groups A (p < .001) and B (p < .01). Two patients (13%) from group B failed to complete the study secondary to vaginal candidiasis.
Conclusion:
Probiotics may be considered a therapeutic option or adjunct for acne vulgaris by providing a synergistic antiinflammatory effect with systemic antibiotics while also reducing potential adverse events secondary to chronic antibiotic use. |
| doi_str_mv | 10.2310/7750.2012.12026 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1327727382</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.2310_7750.2012.12026</sage_id><sourcerecordid>1327727382</sourcerecordid><originalsourceid>FETCH-LOGICAL-c362t-14b54f6c9920a39943f3d4aaf76e44cc06f33d4ff31ac8e867d5937293770cb93</originalsourceid><addsrcrecordid>eNp1kU1v1DAQhiMEoqVw5oYsceGwaf0Ve3OsVuVD2lVRu5wjxxlvvUriEDug5Yfye5jsFoSQOFh-NfPMOyO9Wfaa0UsuGL3SukBFGb9knHL1JDtnihW5ZrR8ippTkUtdyLPsRYx7SiljhXyenXFRLDlTxXn28_MY4gA2-W-wIHemb0Lnf0CzILcD9Pna1NCS7ehNS1ahG8zo-x1JD0DujYN0WJAb57w1FhXOkm1oYTS1b306kOCwRq5tD-gAJnXQJ3IHO4-CfPfp4TgyizAlYgieUvuQvCX30zC0cORnZOP7YA-29ejke-zWe7w4njw2vm1ICmQTGlyd4LjwZfbMmTbCq8f_Ivvy_ma7-pivbz98Wl2vcysUTzmTdSGdsmXJqRFlKYUTjTTGaQVSWkuVE1hwTjBjl7BUuilKoTk-TW1diovs3cl3GMPXCWKqOh8ttK3pIUyxYoJrzbVYckTf_oPuwzT2eB1SUmkmFKNIXZ0oi7nEEVw1jL4z46FitJojr-bIqzny6hg5Trx59J3qDpo__O-MEVicgGh28NfS__j9ApzmtQQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1346713610</pqid></control><display><type>article</type><title>Prospective, Randomized, Open-Label Trial Comparing the Safety, Efficacy, and Tolerability of an Acne Treatment Regimen with and without a Probiotic Supplement and Minocycline in Subjects with Mild to Moderate Acne</title><source>SAGE</source><creator>Jung, Gordon W. ; Tse, Jennifer E. ; Guiha, Isabella ; Rao, Jaggi</creator><creatorcontrib>Jung, Gordon W. ; Tse, Jennifer E. ; Guiha, Isabella ; Rao, Jaggi</creatorcontrib><description>Background:
Systemic antibiotics are an effective treatment for acne vulgaris. However, intolerable side effects may invariably occur.
Objective:
To determine whether probiotics reduce the side effects imparted by systemic antibiotics while working synergistically with the latter in treating inflammatory acne.
Methods:
Forty-five 18- to 35-year-old females were randomly assigned to one of three arms in this prospective, open-label study. Group A received probiotic supplementation, whereas group B received only minocycline. Group C was treated with both probiotic and minocycline. Clinical and subjective assessments were completed at baseline and during the 2-, 4-, 8-, and 12-week follow-up visits.
Results:
All patients demonstrated a significant improvement in total lesion count 4 weeks after treatment initiation (p < .001), with continued improvement seen with each subsequent follow-up visit (p < .01). At the 8- and 12-week follow-up visits, group C had a significant decrease in total lesion count versus groups A (p < .001) and B (p < .01). Two patients (13%) from group B failed to complete the study secondary to vaginal candidiasis.
Conclusion:
Probiotics may be considered a therapeutic option or adjunct for acne vulgaris by providing a synergistic antiinflammatory effect with systemic antibiotics while also reducing potential adverse events secondary to chronic antibiotic use.</description><identifier>ISSN: 1203-4754</identifier><identifier>EISSN: 1615-7109</identifier><identifier>DOI: 10.2310/7750.2012.12026</identifier><identifier>PMID: 23582165</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Acne ; Acne Vulgaris - drug therapy ; Adolescent ; Adult ; Anti-Bacterial Agents - adverse effects ; Anti-Bacterial Agents - therapeutic use ; Antibiotics ; Bifidobacterium ; Clinical trials ; Drug Synergism ; Drug Therapy, Combination ; Female ; Humans ; Lactobacillus acidophilus ; Lactobacillus delbrueckii ; Minocycline - adverse effects ; Minocycline - therapeutic use ; Probiotics ; Probiotics - therapeutic use ; Quality of Life ; Studies ; Young Adult</subject><ispartof>Journal of cutaneous medicine and surgery, 2013-03, Vol.17 (2), p.114-122</ispartof><rights>2013 Canadian Dermatology Association</rights><rights>Copyright Decker Periodicals, Inc. Mar/Apr 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-14b54f6c9920a39943f3d4aaf76e44cc06f33d4ff31ac8e867d5937293770cb93</citedby><cites>FETCH-LOGICAL-c362t-14b54f6c9920a39943f3d4aaf76e44cc06f33d4ff31ac8e867d5937293770cb93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906,79113</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23582165$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jung, Gordon W.</creatorcontrib><creatorcontrib>Tse, Jennifer E.</creatorcontrib><creatorcontrib>Guiha, Isabella</creatorcontrib><creatorcontrib>Rao, Jaggi</creatorcontrib><title>Prospective, Randomized, Open-Label Trial Comparing the Safety, Efficacy, and Tolerability of an Acne Treatment Regimen with and without a Probiotic Supplement and Minocycline in Subjects with Mild to Moderate Acne</title><title>Journal of cutaneous medicine and surgery</title><addtitle>J Cutan Med Surg</addtitle><description>Background:
Systemic antibiotics are an effective treatment for acne vulgaris. However, intolerable side effects may invariably occur.
Objective:
To determine whether probiotics reduce the side effects imparted by systemic antibiotics while working synergistically with the latter in treating inflammatory acne.
Methods:
Forty-five 18- to 35-year-old females were randomly assigned to one of three arms in this prospective, open-label study. Group A received probiotic supplementation, whereas group B received only minocycline. Group C was treated with both probiotic and minocycline. Clinical and subjective assessments were completed at baseline and during the 2-, 4-, 8-, and 12-week follow-up visits.
Results:
All patients demonstrated a significant improvement in total lesion count 4 weeks after treatment initiation (p < .001), with continued improvement seen with each subsequent follow-up visit (p < .01). At the 8- and 12-week follow-up visits, group C had a significant decrease in total lesion count versus groups A (p < .001) and B (p < .01). Two patients (13%) from group B failed to complete the study secondary to vaginal candidiasis.
Conclusion:
Probiotics may be considered a therapeutic option or adjunct for acne vulgaris by providing a synergistic antiinflammatory effect with systemic antibiotics while also reducing potential adverse events secondary to chronic antibiotic use.</description><subject>Acne</subject><subject>Acne Vulgaris - drug therapy</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Anti-Bacterial Agents - adverse effects</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibiotics</subject><subject>Bifidobacterium</subject><subject>Clinical trials</subject><subject>Drug Synergism</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Humans</subject><subject>Lactobacillus acidophilus</subject><subject>Lactobacillus delbrueckii</subject><subject>Minocycline - adverse effects</subject><subject>Minocycline - therapeutic use</subject><subject>Probiotics</subject><subject>Probiotics - therapeutic use</subject><subject>Quality of Life</subject><subject>Studies</subject><subject>Young Adult</subject><issn>1203-4754</issn><issn>1615-7109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp1kU1v1DAQhiMEoqVw5oYsceGwaf0Ve3OsVuVD2lVRu5wjxxlvvUriEDug5Yfye5jsFoSQOFh-NfPMOyO9Wfaa0UsuGL3SukBFGb9knHL1JDtnihW5ZrR8ippTkUtdyLPsRYx7SiljhXyenXFRLDlTxXn28_MY4gA2-W-wIHemb0Lnf0CzILcD9Pna1NCS7ehNS1ahG8zo-x1JD0DujYN0WJAb57w1FhXOkm1oYTS1b306kOCwRq5tD-gAJnXQJ3IHO4-CfPfp4TgyizAlYgieUvuQvCX30zC0cORnZOP7YA-29ejke-zWe7w4njw2vm1ICmQTGlyd4LjwZfbMmTbCq8f_Ivvy_ma7-pivbz98Wl2vcysUTzmTdSGdsmXJqRFlKYUTjTTGaQVSWkuVE1hwTjBjl7BUuilKoTk-TW1diovs3cl3GMPXCWKqOh8ttK3pIUyxYoJrzbVYckTf_oPuwzT2eB1SUmkmFKNIXZ0oi7nEEVw1jL4z46FitJojr-bIqzny6hg5Trx59J3qDpo__O-MEVicgGh28NfS__j9ApzmtQQ</recordid><startdate>201303</startdate><enddate>201303</enddate><creator>Jung, Gordon W.</creator><creator>Tse, Jennifer E.</creator><creator>Guiha, Isabella</creator><creator>Rao, Jaggi</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201303</creationdate><title>Prospective, Randomized, Open-Label Trial Comparing the Safety, Efficacy, and Tolerability of an Acne Treatment Regimen with and without a Probiotic Supplement and Minocycline in Subjects with Mild to Moderate Acne</title><author>Jung, Gordon W. ; Tse, Jennifer E. ; Guiha, Isabella ; Rao, Jaggi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-14b54f6c9920a39943f3d4aaf76e44cc06f33d4ff31ac8e867d5937293770cb93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acne</topic><topic>Acne Vulgaris - drug therapy</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Anti-Bacterial Agents - adverse effects</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibiotics</topic><topic>Bifidobacterium</topic><topic>Clinical trials</topic><topic>Drug Synergism</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Humans</topic><topic>Lactobacillus acidophilus</topic><topic>Lactobacillus delbrueckii</topic><topic>Minocycline - adverse effects</topic><topic>Minocycline - therapeutic use</topic><topic>Probiotics</topic><topic>Probiotics - therapeutic use</topic><topic>Quality of Life</topic><topic>Studies</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jung, Gordon W.</creatorcontrib><creatorcontrib>Tse, Jennifer E.</creatorcontrib><creatorcontrib>Guiha, Isabella</creatorcontrib><creatorcontrib>Rao, Jaggi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cutaneous medicine and surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jung, Gordon W.</au><au>Tse, Jennifer E.</au><au>Guiha, Isabella</au><au>Rao, Jaggi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prospective, Randomized, Open-Label Trial Comparing the Safety, Efficacy, and Tolerability of an Acne Treatment Regimen with and without a Probiotic Supplement and Minocycline in Subjects with Mild to Moderate Acne</atitle><jtitle>Journal of cutaneous medicine and surgery</jtitle><addtitle>J Cutan Med Surg</addtitle><date>2013-03</date><risdate>2013</risdate><volume>17</volume><issue>2</issue><spage>114</spage><epage>122</epage><pages>114-122</pages><issn>1203-4754</issn><eissn>1615-7109</eissn><abstract>Background:
Systemic antibiotics are an effective treatment for acne vulgaris. However, intolerable side effects may invariably occur.
Objective:
To determine whether probiotics reduce the side effects imparted by systemic antibiotics while working synergistically with the latter in treating inflammatory acne.
Methods:
Forty-five 18- to 35-year-old females were randomly assigned to one of three arms in this prospective, open-label study. Group A received probiotic supplementation, whereas group B received only minocycline. Group C was treated with both probiotic and minocycline. Clinical and subjective assessments were completed at baseline and during the 2-, 4-, 8-, and 12-week follow-up visits.
Results:
All patients demonstrated a significant improvement in total lesion count 4 weeks after treatment initiation (p < .001), with continued improvement seen with each subsequent follow-up visit (p < .01). At the 8- and 12-week follow-up visits, group C had a significant decrease in total lesion count versus groups A (p < .001) and B (p < .01). Two patients (13%) from group B failed to complete the study secondary to vaginal candidiasis.
Conclusion:
Probiotics may be considered a therapeutic option or adjunct for acne vulgaris by providing a synergistic antiinflammatory effect with systemic antibiotics while also reducing potential adverse events secondary to chronic antibiotic use.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>23582165</pmid><doi>10.2310/7750.2012.12026</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of cutaneous medicine and surgery, 2013-03, Vol.17 (2), p.114-122 |
| issn | 1203-4754 1615-7109 |
| language | eng |
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| source | SAGE |
| subjects | Acne Acne Vulgaris - drug therapy Adolescent Adult Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - therapeutic use Antibiotics Bifidobacterium Clinical trials Drug Synergism Drug Therapy, Combination Female Humans Lactobacillus acidophilus Lactobacillus delbrueckii Minocycline - adverse effects Minocycline - therapeutic use Probiotics Probiotics - therapeutic use Quality of Life Studies Young Adult |
| title | Prospective, Randomized, Open-Label Trial Comparing the Safety, Efficacy, and Tolerability of an Acne Treatment Regimen with and without a Probiotic Supplement and Minocycline in Subjects with Mild to Moderate Acne |
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