Surveillance of lymphatic filariasis after stopping ten years of mass drug administration in rural communities in south India

Background While various studies provided insight into the impact of mass drug administration (MDA), information on the dynamics of the post-MDA threshold level lymphatic filariasis (LF) infection facilitates understanding its disappearance pattern and determining the duration of post-MDA monitoring...

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Bibliographic Details
Published in:Transactions of the Royal Society of Tropical Medicine and Hygiene 2013-05, Vol.107 (5), p.293-300
Main Authors: Ramaiah, K.D., Vanamail, P.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Animals
Biological and medical sciences
Child
Child, Preschool
Diseases caused by nematodes
Drug Administration Schedule
Drug Monitoring
Elephantiasis, Filarial - epidemiology
Elephantiasis, Filarial - immunology
Elephantiasis, Filarial - transmission
Female
Filariases
General aspects
Helminthic diseases
Humans
India - epidemiology
Infant
Infectious diseases
Lymphatic filariases
Male
Medical sciences
Middle Aged
Parasitic diseases
Rural Population
Young Adult
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Summary:Background While various studies provided insight into the impact of mass drug administration (MDA), information on the dynamics of the post-MDA threshold level lymphatic filariasis (LF) infection facilitates understanding its disappearance pattern and determining the duration of post-MDA monitoring and evaluation. Methods The changes in microfilaraemia (Mf) prevalence and vector infection rates were monitored for four (2005-2008) and six years (2005-2010) respectively after stopping ten rounds of annual mass diethylcarbamazine (DEC) administration in a group of five villages located in South India. Four years after stopping MDA, circulating filarial antigenaemia (Ag) status among children and adults was also assessed in two villages. Results Overall Mf prevalence (n = 700) and vector infection rates (n=803-3520) showed a declining trend. Two villages maintained zero Mf status in each of the four years, vector infection rate was zero from the third year onwards and Ag prevalence in adults was 0.4% (n = 226). In two other villages despite persistence of Mf and vector infection there was zero vector infectivity rate during the third to sixth year and Ag prevalence among children (n = 50) was nil. In the fifth village Mf prevailed at
ISSN:0035-9203
1878-3503
DOI:10.1093/trstmh/trt011