Peroxisome proliferator-activated receptor gamma, a possible culprit in mycosis fungoides: an immunohistochemical study

• Published in: Journal of the European Academy of Dermatology and Venereology 2012-12, Vol.26 (12), p.1522-1532
• Main Authors: Youssef, R., Hegazy, R.A., Fawzy, M.M., Abdel Halim, D.M., Nabil, N., Sayed, S.S., Shaker, O.G.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Blotting, Western; Case-Control Studies; Female; Humans; Immunohistochemistry; Male; Middle Aged; Mycosis Fungoides - metabolism; Mycosis Fungoides - physiopathology; PPAR gamma - metabolism; PPAR gamma - physiology; Prospective Studies; Proto-Oncogene Proteins c-bcl-2 - metabolism; Young Adult
• ISSN: 0926-9959; 1468-3083
• DOI: 10.1111/j.1468-3083.2011.04333.x

Background  It still remains debatable whether peroxisome proliferator‐activated receptor gamma (PPARγ) is pro‐ or antineoplastic, and its exact role in mycosis fungoides (MF) remains unclear. Objective  This prospective comparative study aimed to investigate the expression of PPARγ in MF and compare it with psoriatics and controls in a trial to deduce its possible role in MF. Also, we tried to clarify the relation between PPARγ and Bcl‐2 in MF. Methods  Twenty MF patients, 20 psoriatic patients and 20 controls were included. All participants underwent a skin biopsy, and immunohistochemical staining for both PPARγ and Bcl‐2 were performed. Western blot analysis was performed for detection of both PPARγ and Bcl‐2. Results  The mean area per cent of PPARγ measured in the MF patients (57.1217 ± 9.502417) was significantly higher (P