Antilipidemic activity of organic solvent extract from Sorghum bicolor on rats with diet-induced obesity

The present study evaluated the antiobesity and lipid-lowering effects from dichloromethane and ethyl acetate extracts of Hwanggeumchal Sorghum varieties on Sorghum bicolor. The Hwanggeumchal Sorghum ethyl acetate extracts significantly reduced the plasma total cholesterol and triglyceride levels si...

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Bibliographic Details
Published in:Human & Experimental Toxicology 2011-11, Vol.30 (11), p.1865-1868
Main Authors: Chung, Ill-Min, Yeo, Min-A, Kim, Sun-Jin, Kim, Myong-Jo, Park, Dong-Sik, Moon, Hyung-In
Format: Article
Language:English
Subjects:
Acetates - chemistry
Animals
Anti-Obesity Agents - therapeutic use
Biological and medical sciences
Chemical and industrial products toxicology. Toxic occupational diseases
Cholesterol
Diet, High-Fat
Grain
Hypolipidemic Agents - therapeutic use
Lipids - blood
Male
Medical sciences
Metabolic diseases
Methylene Chloride - chemistry
Obesity
Obesity - blood
Obesity - drug therapy
Phytochemicals
Phytotherapy
Plant Extracts - therapeutic use
Rats
Rats, Wistar
Rodents
Solvents
Solvents - chemistry
Sorghum
Sorghum bicolor
Toxicology
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Summary:The present study evaluated the antiobesity and lipid-lowering effects from dichloromethane and ethyl acetate extracts of Hwanggeumchal Sorghum varieties on Sorghum bicolor. The Hwanggeumchal Sorghum ethyl acetate extracts significantly reduced the plasma total cholesterol and triglyceride levels significantly when given orally at a dose of 50 and 300 mg/kg/day to the high-fat diet-induced obese rats for 2 weeks. These findings demonstrate the excellent pharmacological potential of Hwanggeumchal Sorghum varieties to prevent obesity.
ISSN:0960-3271
1477-0903
DOI:10.1177/0960327110390066