Inducing Rapid Cellular Response on RGD-Binding Threaded Macromolecular Surfaces

The rapid response of integrin β1 molecules to an RGD peptide on a dynamic polyrotaxane surface was successfully induced. As a result, RGD peptides introduced on a highly dynamic cyclodextrin molecule enhanced the frequency of contact with specific integrin molecules on the cell membrane at the earl...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2013-04, Vol.135 (15), p.5513-5516
Main Authors: Seo, Ji-Hun, Kakinoki, Sachiro, Inoue, Yuuki, Yamaoka, Tetsuji, Ishihara, Kazuhiko, Yui, Nobuhiko
Format: Article
Language:English
Subjects:
alpha-Cyclodextrins - metabolism
Cell Adhesion
Human Umbilical Vein Endothelial Cells - cytology
Human Umbilical Vein Endothelial Cells - metabolism
Humans
Integrins - metabolism
Oligopeptides - metabolism
Surface Properties
Time Factors
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Summary:The rapid response of integrin β1 molecules to an RGD peptide on a dynamic polyrotaxane surface was successfully induced. As a result, RGD peptides introduced on a highly dynamic cyclodextrin molecule enhanced the frequency of contact with specific integrin molecules on the cell membrane at the early stage of material–cell interactions.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja400817q