Identification and validation that up-expression of HOXA13 is a novel independent prognostic marker of a worse outcome in gastric cancer based on immunohistochemistry

Homeobox (HOX) gene family is known to be classic examples of the intimate relationship between embryogenesis and tumorigenesis. However, less is known about the involvement of HOX gene family with gastric cancerogenesis. Here, we screened the expression of HOX gene family in gastric cancers and exp...

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Bibliographic Details
Published in:Medical oncology (Northwood, London, England) London, England), 2013-06, Vol.30 (2), p.564-564, Article 564
Main Authors: Han, Yang, Tu, Wei-wei, Wen, Yu-gang, Li, Da-peng, Qiu, Guo-qiang, Tang, Hua-mei, Peng, Zhi-hai, Zhou, Chong-zhi
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Analysis of Variance
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Chi-Square Distribution
Cohort Studies
Female
Gastric Mucosa - chemistry
Gastric Mucosa - metabolism
Hematology
Homeodomain Proteins - genetics
Homeodomain Proteins - metabolism
Humans
Immunohistochemistry
Internal Medicine
Kaplan-Meier Estimate
Male
Medicine
Medicine & Public Health
Middle Aged
Oncology
Original Paper
Pathology
Prognosis
Reproducibility of Results
Stomach Neoplasms - diagnosis
Stomach Neoplasms - genetics
Stomach Neoplasms - metabolism
Stomach Neoplasms - pathology
Up-Regulation
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Summary:Homeobox (HOX) gene family is known to be classic examples of the intimate relationship between embryogenesis and tumorigenesis. However, less is known about the involvement of HOX gene family with gastric cancerogenesis. Here, we screened the expression of HOX gene family in gastric cancers and explored the relationships between them by cDNA microarray. We found several differentially expressed HOX genes in gastric cancers, especially HOXA10 (11/12) and HOXA13 (11/12) with significantly higher expression in the cancerous tissues. Furthermore, we validated HOXA13 as a novel prognostic marker in gastric cancer based on immunohistochemistry and statistical analysis. HOXA13 expression was significantly up-regulated in cancerous tissues compared with the corresponding non-cancerous mucosa ( P  
ISSN:1357-0560
1559-131X
DOI:10.1007/s12032-013-0564-1