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Impact of pre‐treatment prostate tissue androgen content on the prediction of castration‐resistant prostate cancer development in patients treated with primary androgen deprivation therapy

Summary Great advances in tissue androgen analysis using liquid chromatography‐tandem mass spectrometry (LC‐MS/MS) have made it possible to evaluate the tissue androgen content from a single needle prostate biopsy specimen. In this study, we investigated if pre‐treatment androgen content in prostate...

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Bibliographic Details
Published in:Andrology (Oxford) 2013-05, Vol.1 (3), p.505-511
Main Authors: Shibata, Y., Suzuki, K., Arai, S., Miyoshi, Y., Umemoto, S., Masumori, N., Kamiya, N., Ichikawa, T., Kitagawa, Y., Mizokami, A., Sugimura, Y., Nonomura, N., Sakai, H., Honma, S., Kubota, Y.
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Language:English
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Summary:Summary Great advances in tissue androgen analysis using liquid chromatography‐tandem mass spectrometry (LC‐MS/MS) have made it possible to evaluate the tissue androgen content from a single needle prostate biopsy specimen. In this study, we investigated if pre‐treatment androgen content in prostate biopsy specimens could predict their response to primary androgen deprivation therapy (ADT) and future castration‐resistant prostate cancer (CRPC). One‐hundred and sixty‐five prostate cancer patients who received primary ADT were enrolled. They had received multiple core prostate needle biopsy at diagnosis, and an additional one needle biopsy specimen was obtained for tissue androgen determination using LC‐MS/MS. The patients' prostate specific antigen (PSA) values were periodically followed during the treatment and patients were determined to have CRPC when their PSA value increased continuously to 25% above the nadir and a 2.0 ng/mL increase. A significant correlation was found between PSA value decline velocity (PSA half‐time) after ADT and pre‐ADT tissue androgen content. Twenty‐three patients were determined to have CRPC. These CRPC patients had a significantly high concentration of tissue T (p 
ISSN:2047-2919
2047-2927
DOI:10.1111/j.2047-2927.2013.00068.x