Siah: A Promising Anticancer Target

Siah ubiquitin ligases play important roles in a number of signaling pathways involved in the progression and spread of cancer in cell-based models, but their role in tumor progression remains controversial. Siah proteins have been described to be both oncogenic and tumor suppressive in a variety of...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 2013-04, Vol.73 (8), p.2400-2406
Main Authors: WONG, Christina S. F, MÖLLER, Andreas
Format: Article
Language:English
Subjects:
Animals
Antineoplastic agents
Biological and medical sciences
Disease Models, Animal
Humans
Medical sciences
Molecular Targeted Therapy
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - therapy
Nuclear Proteins - antagonists & inhibitors
Nuclear Proteins - genetics
Nuclear Proteins - metabolism
Oncogene Proteins - genetics
Oncogene Proteins - metabolism
Pharmacology. Drug treatments
Tumor Suppressor Proteins - genetics
Tumor Suppressor Proteins - metabolism
Tumors
Ubiquitin-Protein Ligases - antagonists & inhibitors
Ubiquitin-Protein Ligases - genetics
Ubiquitin-Protein Ligases - metabolism
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Summary:Siah ubiquitin ligases play important roles in a number of signaling pathways involved in the progression and spread of cancer in cell-based models, but their role in tumor progression remains controversial. Siah proteins have been described to be both oncogenic and tumor suppressive in a variety of patient cohort studies and animal cancer models. This review collates the current knowledge of Siah in cancer progression and identifies potential methods of translation of these findings into the clinic. Furthermore, key experiments needed to close the gaps in our understanding of the role Siah proteins play in tumor progression are suggested.
ISSN:0008-5472
1538-7445
DOI:10.1158/0008-5472.CAN-12-4348