Factor VII assay performance: an analysis of the North American Specialized Coagulation Laboratory Association proficiency testing results

• Published in: International journal of laboratory hematology 2013-06, Vol.35 (3), p.314-321
• Main Authors: Zantek, N. D., Hsu, P., Refaai, M. A., Ledford-Kraemer, M., Meijer, P., Van Cott, E. M.
• Format: Article
• Language: English
• Subjects: Animals; Blood Coagulation Tests - methods; Blood Coagulation Tests - standards; Blood Coagulation Tests - statistics & numerical data; Calibration; Canada; external quality control of diagnostic assays and tests; Factor VII; Factor VII - analysis; Factor VII - standards; Factor VII Deficiency - blood; Factor VII Deficiency - diagnosis; Humans; Laboratories - standards; Laboratories - statistics & numerical data; Laboratory Proficiency Testing - methods; Laboratory Proficiency Testing - standards; Laboratory Proficiency Testing - statistics & numerical data; North American specialized coagulation laboratory association; Rabbits; Reference Values; Reproducibility of Results; Sensitivity and Specificity; thromboplastin; Thromboplastin - standards; United States
• ISSN: 1751-5521; 1751-553X
• DOI: 10.1111/ijlh.12083

Summary The performance of factor VII (FVII) assays currently used by clinical laboratories was examined in North American Specialized Coagulation Laboratory Association (NASCOLA) proficiency tests. Data from 12 surveys conducted between 2008 and 2010, involving 20 unique specimens plus four repeat‐tested specimens, were analyzed. The number of laboratories per survey was 49–54 with a total of 1224 responses. Numerous reagent/instrument combinations were used. For FVII > 80 or