A gold(III) porphyrin complex as an anti-cancer candidate to inhibit growth of cancer-stem cells

A cytotoxic gold(III) complex of meso-tetraphenylporphyrin ([Au(TPP)]Cl, denoted gold-1a) blocks the self-renewal ability of cancer stem-like cells and shows appealing safety pharmacological profiles in rodents.

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2013-05, Vol.49 (39), p.4364-4366
Main Authors: Lum, Ching Tung, Wong, Alice Sze-Tsai, Lin, Marie C M, Che, Chi-Ming, Sun, Raymond Wai-Yin
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - toxicity
Cell Line, Tumor
Cell Survival - drug effects
Coordination Complexes - chemical synthesis
Coordination Complexes - chemistry
Coordination Complexes - toxicity
Gold - chemistry
Humans
Mice
MicroRNAs - metabolism
Neoplastic Stem Cells - drug effects
Porphyrins - chemistry
RNA, Small Nuclear - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A cytotoxic gold(III) complex of meso-tetraphenylporphyrin ([Au(TPP)]Cl, denoted gold-1a) blocks the self-renewal ability of cancer stem-like cells and shows appealing safety pharmacological profiles in rodents.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc37366a