Clinical-pathologic features, long term-outcome and surgical treatment in a large series of patients with invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC)

Abstract Purpose of the study A retrospective analysis on 1407 patients with invasive ductal carcinoma (IDC) and 243 invasive lobular carcinoma (ILC) was performed in order to compare the histological features, the immunohistochemical characteristics, the surgical treatment and the clinical outcome...

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Bibliographic Details
Published in:European journal of surgical oncology 2013-05, Vol.39 (5), p.455-460
Main Authors: Biglia, N, Maggiorotto, F, Liberale, V, Bounous, V.E, Sgro, L.G, Pecchio, S, D'Alonzo, M, Ponzone, R
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Analysis of Variance
Breast cancer
Breast cancer prognosis
Breast conserving treatment
Breast Neoplasms - pathology
Breast Neoplasms - radiotherapy
Breast Neoplasms - surgery
Carcinoma, Ductal, Breast - pathology
Carcinoma, Ductal, Breast - radiotherapy
Carcinoma, Ductal, Breast - surgery
Carcinoma, Lobular - pathology
Carcinoma, Lobular - radiotherapy
Carcinoma, Lobular - surgery
Chi-Square Distribution
Female
Hematology, Oncology and Palliative Medicine
Humans
In Situ Hybridization, Fluorescence
Infiltrating ductal carcinoma
Infiltrating lobular carcinoma
Logistic Models
Mastectomy, Segmental
Middle Aged
Neoplasm Invasiveness
Reoperation
Retrospective Studies
Risk Factors
Sentinel Lymph Node Biopsy
Surgery
Surgical treatment
Survival Rate
Treatment Outcome
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Summary:Abstract Purpose of the study A retrospective analysis on 1407 patients with invasive ductal carcinoma (IDC) and 243 invasive lobular carcinoma (ILC) was performed in order to compare the histological features, the immunohistochemical characteristics, the surgical treatment and the clinical outcome in the two groups. Results ILC seems to be more likely multifocal, estrogen receptor positive, HER-2 negative and to have a lower proliferative index compared to IDC. ILC, when treated with conservative surgery, required more frequently re-excision and/or mastectomy because of positive resection margins. No difference was observed in terms of 5-year disease free survival and local relapse free survival between the two groups, in the whole series and in the subgroup of patients treated with breast-conserving treatment. Conclusion ILC can be safely treated with conservative surgery but a more accurate preoperative evaluation of tumor size and multifocality could be advocated, in order to reduce the re-excision rate.
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2013.02.007