Tianeptine facilitates spreading depression in well-nourished and early-malnourished adult rats

• Published in: European journal of pharmacology 2013-04, Vol.706 (1-3), p.70-75
• Main Authors: Amancio-dos-Santos, Angela, Maia, Luciana Maria Silva de Seixas, Germano, Paula Catirina Pereira da Silva, Negrão, Yleana Danielle dos Santos, Guedes, Rubem Carlos Araújo
• Format: Article
• Language: English
• Subjects: Administration, Topical; adults; Animals; Animals, Newborn; Antidepressive Agents, Tricyclic - administration & dosage; brain; Brain development; Cerebral Cortex - drug effects; Cerebral Cortex - physiology; Cortical spreading depression; drugs; Injections, Subcutaneous; Malnutrition; nutritional status; Nutritional Status - physiology; pups; Rat; Rats; Rats, Wistar; serotonin; Serotoninergic system; Thiazepines - administration & dosage; Tianeptine; topical application
• ISSN: 0014-2999; 1879-0712
• DOI: 10.1016/j.ejphar.2013.02.047

Nutritional status during development can modify the brain's electrophysiological properties and its response to drugs that reduce the serotonin availability in the synaptic cleft. Here we used cortical spreading depression (CSD) in the rat as a neurophysiological parameter to investigate the interaction between nutritional status and treatment with tianeptine, a serotonin uptake enhancer. From postnatal day 2 to 24, well-nourished and early-malnourished rat pups were s.c. injected with tianeptine (5 or 10mg/kg; 10ml/kg) or equivalent volume of saline solution (control group). When the animals were 25–30 days old, CSD was recorded on the brain cortical surface. In the well-nourished rats, but not in the malnourished group, systemic tianeptine dose-dependently increased the CSD propagation velocity, with 10mg/kg producing a significant (P