RKIP: Much more than Raf Kinase inhibitory protein

From its discovery as a phosphatidylethanolamine‐binding protein in bovine brain to its designation as a physiological inhibitor of Raf kinase protein, RKIP has emerged as a critical molecule for maintaining subdued, well‐orchestrated cellular responses to stimuli. The disruption of RKIP in a wide r...

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Bibliographic Details
Published in:Journal of cellular physiology 2013-08, Vol.228 (8), p.1688-1702
Main Authors: Al-Mulla, Fahd, Bitar, Milad S., Taqi, Zainab, Yeung, Kam C.
Format: Article
Language:English
Subjects:
Alzheimer's disease
Animals
Apoptosis
Apoptosis - genetics
Base Sequence
Brain
Cancer
Cattle
Cell Movement - genetics
Cell Proliferation
Drug Resistance - genetics
Enzyme inhibitors
Genome, Human
Humans
Intracellular signalling
MAP Kinase Signaling System - genetics
Models, Molecular
Molecular Sequence Data
Neurodegenerative diseases
Pancreatitis
Phosphatidylethanolamine
Phosphatidylethanolamine Binding Protein - chemistry
Phosphatidylethanolamine Binding Protein - genetics
Phosphatidylethanolamine Binding Protein - physiology
Proteins
raf Kinases - antagonists & inhibitors
Raf protein
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Summary:From its discovery as a phosphatidylethanolamine‐binding protein in bovine brain to its designation as a physiological inhibitor of Raf kinase protein, RKIP has emerged as a critical molecule for maintaining subdued, well‐orchestrated cellular responses to stimuli. The disruption of RKIP in a wide range of pathologies, including cancer, Alzheimer's disease, and pancreatitis, makes it an exciting target for individualized therapy and disease‐specific interventions. This review attempts to highlight recent advances in the RKIP field underscoring its potential role as a master modulator of many pivotal intracellular signaling cascades that control cellular growth, motility, apoptosis, genomic integrity, and therapeutic resistance. Specific biological and functional niches are highlighted to focus future research towards an enhanced understanding of the multiple roles of RKIP in health and disease. J. Cell. Physiol. 228: 1688–1702, 2013. © 2013 Wiley Periodicals, Inc.
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.24335