Myristoylated Alanine-Rich protein Kinase C Substrate (MARCKS) expression modulates the metastatic phenotype in human and murine colon carcinoma in vitro and in vivo

Highlights ► MARCKS is a frequent target of mutation in CRC with high-level microsatellite instability (MSI-H). ► Changing MARCKS content in CRC human and murine cell lines affects tumour-associated processes i.e. proliferation, migration and invasion. ► Loss of MARCKS protein hampers dynamic actin...

Full description

Saved in:
Bibliographic Details
Published in:Cancer letters 2013-06, Vol.333 (2), p.244-252
Main Authors: Rombouts, Krista, Carloni, Vinicio, Mello, Tommaso, Omenetti, Sara, Galastri, Sara, Madiai, Stefania, Galli, Andrea, Pinzani, Massimo
Format: Article
Language:English
Subjects:
Actin reorganization
Actins - metabolism
Animals
Aurora B kinase/AIM-1
Aurora Kinase B
Aurora Kinases
Cell Line, Tumor
cell movement
Cell Movement - genetics
chemoattractants
colon
Colonic Neoplasms - genetics
Colonic Neoplasms - pathology
colorectal neoplasms
Colorectal Neoplasms - genetics
Colorectal Neoplasms - pathology
frameshift mutation
Gene Expression Regulation, Neoplastic
Hematology, Oncology and Palliative Medicine
Hepatic Stellate Cells - metabolism
Humans
Intracellular Signaling Peptides and Proteins - genetics
Intracellular Signaling Peptides and Proteins - metabolism
Invasion/migration
Liver Neoplasms, Experimental - pathology
Liver Neoplasms, Experimental - secondary
MARCKS
Membrane Proteins - genetics
Membrane Proteins - metabolism
metastasis
Mice
Mice, Inbred BALB C
microfilament proteins
Mitosis
Myristoylated Alanine-Rich C Kinase Substrate
pathogenesis
phenotype
protein kinase C
Protein-Serine-Threonine Kinases - genetics
Protein-Serine-Threonine Kinases - metabolism
RNA, Small Interfering
stromal cells
Stromal Cells - metabolism
Stromal Cells - pathology
Syngeneic-orthotopic murine model
Tumour stromal cells
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights ► MARCKS is a frequent target of mutation in CRC with high-level microsatellite instability (MSI-H). ► Changing MARCKS content in CRC human and murine cell lines affects tumour-associated processes i.e. proliferation, migration and invasion. ► Loss of MARCKS protein hampers dynamic actin reorganization and interferes with the tumour-stromal cross talk between CRC and hHSCs. ► MARCKS might represent a suitable target to interfere and overcome the invasive behaviour of colon carcinoma cells at primary and distant sites.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2013.01.040