Cell cycle arrest and apoptosis induced by O -acetyl-GD2-specific monoclonal antibody 8B6 inhibits tumor growth in vitro and in vivo

Highlights ► We studied the anti-tumor mechanisms of mAb 8B6 specific to O AcGD2. ► Antibody 8B6 induces tumor cell cycle arrest and tumor cell apoptosis in vitro .. ► Antibody 8B6 triggers the mitochondrial apoptotic pathway with caspase 3 activation. ► Antibody 8B6’s apoptotic properties results i...

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Bibliographic Details
Published in:Cancer letters 2013-06, Vol.333 (2), p.194-204
Main Authors: Cochonneau, Denis, Terme, Mickaël, Michaud, Alexis, Dorvillius, Mylène, Gautier, Nicolas, Frikeche, Jihane, Alvarez-Rueda, Nidia, Bougras, Gwenola, Aubry, Jacques, Paris, François, Birklé, Stéphane
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal - metabolism
Antibodies, Monoclonal - pharmacology
anticarcinogenic activity
antigens
Antineoplastic Agents - pharmacology
Apoptosis
Apoptosis - drug effects
cell cycle
Cell cycle arrest
Cell Cycle Checkpoints - drug effects
Cell Line, Tumor
Cell Survival - drug effects
Ganglioside
gangliosides
Gangliosides - immunology
growth retardation
Hematology, Oncology and Palliative Medicine
Humans
Immunotherapy
Mice
Mice, SCID
monoclonal antibodies
O-Acetyl-GD2
Therapeutic antibody
Xenograft Model Antitumor Assays
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Summary:Highlights ► We studied the anti-tumor mechanisms of mAb 8B6 specific to O AcGD2. ► Antibody 8B6 induces tumor cell cycle arrest and tumor cell apoptosis in vitro .. ► Antibody 8B6 triggers the mitochondrial apoptotic pathway with caspase 3 activation. ► Antibody 8B6’s apoptotic properties results in tumor growth inhibition in vivo.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2013.01.032