Synthesis and biological evaluation of Germanium(IV)–polyphenol complexes as potential anti-cancer agents

Germanium (Ge) is considered to play a key role in the pharmacological effects of some medicinal plants. Here, two new Ge(IV)–polyphenol complexes were synthesized and measured for their potential biological activities. The results indicated that these Ge(IV)–polyphenol complexes possessed great ant...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2013-05, Vol.23 (10), p.2902-2908
Main Authors: Pi, Jiang, Zeng, Jing, Luo, Jian-Jun, Yang, Pei-Hui, Cai, Ji-Ye
Format: Article
Language:English
Subjects:
active ingredients
Anti-cancer
Anti-oxidant
antineoplastic agents
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
antioxidant activity
atomic force microscopy
Atomic force microscopy (AFM)
calves
Cell Proliferation - drug effects
Cell Survival - drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Germanium
Germanium - chemistry
Hep G2 Cells
human cell lines
Humans
medicinal plants
Molecular Structure
Organometallic Compounds - chemical synthesis
Organometallic Compounds - chemistry
Organometallic Compounds - pharmacology
Polyphenols
Polyphenols - chemistry
Structure-Activity Relationship
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Summary:Germanium (Ge) is considered to play a key role in the pharmacological effects of some medicinal plants. Here, two new Ge(IV)–polyphenol complexes were synthesized and measured for their potential biological activities. The results indicated that these Ge(IV)–polyphenol complexes possessed great anti-oxidative activities, both showing stronger hydroxyl scavenging effects than their corresponding ligands. We also demonstrated the strong intercalating abilities of Ge(IV)–polyphenol complexes into calf thymus-DNA molecules. In addition, these two Ge(IV)–polyphenol complexes showed strong proliferative inhibition effect on HepG2 cancer cells. Moreover, the morphological changes in HepG2 cells induced by Ge(IV)–polyphenol complexes were detected by atomic force microscopy. All these results collectively suggested that Ge(IV)–polyphenol complexes could be served as promising pharmacologically active substances against cancer treatment.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2013.03.061