miR-143 inhibits glycolysis and depletes stemness of glioblastoma stem-like cells

Highlights ► miR-143 expression is significantly down-regulated in glioma tissues and GSLCs. ► miR-143 affects glucose metabolism by targeting HK2 in GSLCs. ► miR-143 promotes differentiation and inhibits self-renew of GSLCs under hypoxia. ► Combination of miR-143 and 2-DG has synergistic effects ag...

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Bibliographic Details
Published in:Cancer letters 2013-06, Vol.333 (2), p.253-260
Main Authors: Zhao, Shiguang, Liu, Huailei, Liu, Yaohua, Wu, Jianing, Wang, Chunlei, Hou, Xu, Chen, Xiaofeng, Yang, Guang, Zhao, Ling, Che, Hui, Bi, Yunke, Wang, Hongyu, Peng, Fei, Ai, Jing
Format: Article
Language:English
Subjects:
2-Deoxy-d-glucose (2-DG)
anaerobic conditions
Animals
Base Sequence
Cancer
Cell Differentiation - genetics
Cell Hypoxia - genetics
Cell Line, Tumor
Deoxyglucose - pharmacology
Enzymes
Female
Glioblastoma - drug therapy
Glioblastoma - genetics
Glioblastoma - pathology
Glioblastoma stem-like cells
Glioma - genetics
Glioma - pathology
Glycolysis
Glycolysis - genetics
Hematology, Oncology and Palliative Medicine
hexokinase
Humans
Kinases
Medical prognosis
Metabolism
Mice
Mice, Inbred BALB C
MicroRNAs
MicroRNAs - genetics
miR-143
Molecular Sequence Data
Neoplastic Stem Cells - drug effects
Neoplastic Stem Cells - pathology
Neurosphere
Rats
Stem cells
synergism
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Summary:Highlights ► miR-143 expression is significantly down-regulated in glioma tissues and GSLCs. ► miR-143 affects glucose metabolism by targeting HK2 in GSLCs. ► miR-143 promotes differentiation and inhibits self-renew of GSLCs under hypoxia. ► Combination of miR-143 and 2-DG has synergistic effects against GSLCs.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2013.01.039