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Imidazole Initiates Exsheathing of L3 Teladorsagia circumcincta
The infective larvae of Teladorsagia circumcincta have a protective sheath that is lost soon after they reach the rumen of the sheep (the definitive host). Incubation in vitro with 50 mM imidazole caused more than 75% of L₃ T. circumcincta to begin exsheathing within 2 hr. The initiation of exsheath...
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| Published in: | The Journal of parasitology 2013-04, Vol.99 (2), p.332-336 |
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| Main Authors: | , , , , , |
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| Language: | English |
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| container_end_page | 336 |
| container_issue | 2 |
| container_start_page | 332 |
| container_title | The Journal of parasitology |
| container_volume | 99 |
| creator | Brown, Simon Neale, Jennifer D Nava-Tirado, Magnolia Simpson, Heather V Pedley, Kevin C Simcock, David C |
| description | The infective larvae of Teladorsagia circumcincta have a protective sheath that is lost soon after they reach the rumen of the sheep (the definitive host). Incubation in vitro with 50 mM imidazole caused more than 75% of L₃ T. circumcincta to begin exsheathing within 2 hr. The initiation of exsheathing was less likely at pH 6.2 than at pH 7.8. The apparent pKₐ of this process was 7.08, similar to that for the conversion of imidazolium⁺ to imidazole. Both the extent and the initial rate of exsheathing initiation increased with imidazole concentration (the apparent K½ was about 50 mM). The initial rate of exsheathing initiation was stimulated by lactose and maltose, but not by some other carbohydrates, and by propylamine and imidazole acetic acid, but not by histidine. |
| doi_str_mv | 10.1645/GE-3051.1 |
| format | article |
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Incubation in vitro with 50 mM imidazole caused more than 75% of L₃ T. circumcincta to begin exsheathing within 2 hr. The initiation of exsheathing was less likely at pH 6.2 than at pH 7.8. The apparent pKₐ of this process was 7.08, similar to that for the conversion of imidazolium⁺ to imidazole. Both the extent and the initial rate of exsheathing initiation increased with imidazole concentration (the apparent K½ was about 50 mM). The initial rate of exsheathing initiation was stimulated by lactose and maltose, but not by some other carbohydrates, and by propylamine and imidazole acetic acid, but not by histidine.</description><identifier>ISSN: 0022-3395</identifier><identifier>EISSN: 1937-2345</identifier><identifier>DOI: 10.1645/GE-3051.1</identifier><identifier>PMID: 23043312</identifier><language>eng</language><publisher>United States: American Society of Parasitologists</publisher><subject>acetic acid ; Animals ; Enzyme Inhibitors - pharmacology ; Histamines ; histidine ; Imidazoles ; Imidazoles - pharmacology ; lactose ; Larva - drug effects ; Larva - physiology ; Larvae ; maltose ; Nematode larvae ; Nematodes ; Parasitology ; Rumen ; Rumen - parasitology ; Rumen bacteria ; Rumen fluids ; Sheep ; Sheep Diseases - parasitology ; Teladorsagia circumcincta ; THERAPEUTICS-DIAGNOSTICS ; Trichostrongyloidea - drug effects ; Trichostrongyloidea - physiology ; Trichostrongyloidiasis - parasitology ; Trichostrongyloidiasis - veterinary</subject><ispartof>The Journal of parasitology, 2013-04, Vol.99 (2), p.332-336</ispartof><rights>American Society of Parasitologists 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/41981995$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/41981995$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,58238,58471</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23043312$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brown, Simon</creatorcontrib><creatorcontrib>Neale, Jennifer D</creatorcontrib><creatorcontrib>Nava-Tirado, Magnolia</creatorcontrib><creatorcontrib>Simpson, Heather V</creatorcontrib><creatorcontrib>Pedley, Kevin C</creatorcontrib><creatorcontrib>Simcock, David C</creatorcontrib><title>Imidazole Initiates Exsheathing of L3 Teladorsagia circumcincta</title><title>The Journal of parasitology</title><addtitle>J Parasitol</addtitle><description>The infective larvae of Teladorsagia circumcincta have a protective sheath that is lost soon after they reach the rumen of the sheep (the definitive host). Incubation in vitro with 50 mM imidazole caused more than 75% of L₃ T. circumcincta to begin exsheathing within 2 hr. The initiation of exsheathing was less likely at pH 6.2 than at pH 7.8. The apparent pKₐ of this process was 7.08, similar to that for the conversion of imidazolium⁺ to imidazole. Both the extent and the initial rate of exsheathing initiation increased with imidazole concentration (the apparent K½ was about 50 mM). The initial rate of exsheathing initiation was stimulated by lactose and maltose, but not by some other carbohydrates, and by propylamine and imidazole acetic acid, but not by histidine.</description><subject>acetic acid</subject><subject>Animals</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Histamines</subject><subject>histidine</subject><subject>Imidazoles</subject><subject>Imidazoles - pharmacology</subject><subject>lactose</subject><subject>Larva - drug effects</subject><subject>Larva - physiology</subject><subject>Larvae</subject><subject>maltose</subject><subject>Nematode larvae</subject><subject>Nematodes</subject><subject>Parasitology</subject><subject>Rumen</subject><subject>Rumen - parasitology</subject><subject>Rumen bacteria</subject><subject>Rumen fluids</subject><subject>Sheep</subject><subject>Sheep Diseases - parasitology</subject><subject>Teladorsagia circumcincta</subject><subject>THERAPEUTICS-DIAGNOSTICS</subject><subject>Trichostrongyloidea - drug effects</subject><subject>Trichostrongyloidea - physiology</subject><subject>Trichostrongyloidiasis - parasitology</subject><subject>Trichostrongyloidiasis - veterinary</subject><issn>0022-3395</issn><issn>1937-2345</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNo9kEtLAzEUhYMotj4W_gB1lm6m5uY1yUqk1FoouLBdD9eZpE2ZR51kQP31DrS6ONzF93HhHEJugE5ACfk4n6WcSpjACRmD4VnKuJCnZEwpYynnRo7IRQg7Sqkcck5GjFPBObAxeVrUvsSftrLJovHRY7QhmX2FrcW49c0maV2y5MnKVli2XcCNx6TwXdHXhW-KiFfkzGEV7PXxXpL1y2w1fU2Xb_PF9HmZOshYTAF1hhnXnFptlcFSSZGhc0UpnZIUDHVSOVlCpgqO2jrlSi21GFShmEF-SR4Of_dd-9nbEPPah8JWFTa27UMOQ2MJUmg6qHdHtf-obZnvO19j953_lR6E24OwC7Ht_rkAo8EYOfD7A3fY5rjpfMjX74yCGsajHLTkv5dlaR4</recordid><startdate>201304</startdate><enddate>201304</enddate><creator>Brown, Simon</creator><creator>Neale, Jennifer D</creator><creator>Nava-Tirado, Magnolia</creator><creator>Simpson, Heather V</creator><creator>Pedley, Kevin C</creator><creator>Simcock, David C</creator><general>American Society of Parasitologists</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201304</creationdate><title>Imidazole Initiates Exsheathing of L3 Teladorsagia circumcincta</title><author>Brown, Simon ; 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Incubation in vitro with 50 mM imidazole caused more than 75% of L₃ T. circumcincta to begin exsheathing within 2 hr. The initiation of exsheathing was less likely at pH 6.2 than at pH 7.8. The apparent pKₐ of this process was 7.08, similar to that for the conversion of imidazolium⁺ to imidazole. Both the extent and the initial rate of exsheathing initiation increased with imidazole concentration (the apparent K½ was about 50 mM). The initial rate of exsheathing initiation was stimulated by lactose and maltose, but not by some other carbohydrates, and by propylamine and imidazole acetic acid, but not by histidine.</abstract><cop>United States</cop><pub>American Society of Parasitologists</pub><pmid>23043312</pmid><doi>10.1645/GE-3051.1</doi><tpages>5</tpages></addata></record> |
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| ispartof | The Journal of parasitology, 2013-04, Vol.99 (2), p.332-336 |
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| language | eng |
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| source | JSTOR Archival Journals and Primary Sources Collection |
| subjects | acetic acid Animals Enzyme Inhibitors - pharmacology Histamines histidine Imidazoles Imidazoles - pharmacology lactose Larva - drug effects Larva - physiology Larvae maltose Nematode larvae Nematodes Parasitology Rumen Rumen - parasitology Rumen bacteria Rumen fluids Sheep Sheep Diseases - parasitology Teladorsagia circumcincta THERAPEUTICS-DIAGNOSTICS Trichostrongyloidea - drug effects Trichostrongyloidea - physiology Trichostrongyloidiasis - parasitology Trichostrongyloidiasis - veterinary |
| title | Imidazole Initiates Exsheathing of L3 Teladorsagia circumcincta |
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