Significance of autotaxin activity and overexpression in comparison to soluble intercellular adhesion molecule in thyroid cancer

The objective of this study was to evaluate the role of autotaxin (ATX) activity and gene expression compared to soluble intercellular adhesion molecule-1 (sICAM-1) in thyroid carcinoma.
 Sixty-five patients with thyroid swelling were included. There were 20 cases of simple multinodular goiter (grou...

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Bibliographic Details
Published in:The International journal of biological markers 2013-01, Vol.28 (1), p.84-91
Main Authors: Hassan, Azza M, Alm El-Din, Mohamed A, Nagy, Hala, Ghoneem, Naglaa, El-Heniedy, Mohamed A, Koteb, Nessreen, El-Gohary, Salah
Format: Article
Language:English
Subjects:
Adenoma - enzymology
Carcinoma, Papillary - blood
Carcinoma, Papillary - blood supply
Carcinoma, Papillary - enzymology
Carcinoma, Papillary - secondary
Gene Expression
Goiter - enzymology
Humans
Intercellular Adhesion Molecule-1 - blood
Lymphatic Metastasis
Phosphoric Diester Hydrolases - genetics
Phosphoric Diester Hydrolases - metabolism
Thyroid Neoplasms - blood
Thyroid Neoplasms - enzymology
Thyroid Neoplasms - pathology
Tumor Burden
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Summary:The objective of this study was to evaluate the role of autotaxin (ATX) activity and gene expression compared to soluble intercellular adhesion molecule-1 (sICAM-1) in thyroid carcinoma.
 Sixty-five patients with thyroid swelling were included. There were 20 cases of simple multinodular goiter (group I), 15 cases of follicular adenoma (group II) and 30 cases of thyroid cancer (group III). Group III was further subdivided into negative and positive lymph nodes (group IIIa and IIIb; 22 and 8 cases, respectively). sICAM-1 concentration and ATX activity were measured using colorimetric enzyme-linked immunosorbent assay (ELISA), while ATX gene expression was detected by real-time polymerase chain reaction (PCR).
 sICAM-1 level, ATX activity and gene expression were significantly elevated in patients with thyroid carcinoma compared to other groups. The ATX activity showed significantly higher sensitivity and specificity than sICAM-1 (100% and 97.1% vs 93.3% and 88.6%, respectively). Both sICAM-1 and ATX values were significantly higher in patients with positive lymph nodes compared to those without lymph node involvement (p
ISSN:0393-6155
1724-6008
DOI:10.5301/JBM.2013.10780