Clinical analysis of ovarian epithelial carcinoma with coexisting pelvic endometriosis

Objectives To explore the differences between women with endometiosis associated ovarian cancer and typical epithelial ovarian cancer. Study Design The medical charts of total 226 patients with epithelial ovarian cancer treated at Peking Union Medical College Hospital between March 2011 and March 20...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2013-05, Vol.208 (5), p.413.e1-413.e5
Main Authors: Wang, Shu, MD, PhD, Qiu, Lin, MD, Lang, Jing He, MD, Shen, Keng, MD, Yang, Jia Xin, MD, Huang, Hui Fang, MD, Pan, Ling Ya, MD, Wu, Ming, MD
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
CA-125 Antigen - blood
Carcinoma, Ovarian Epithelial
endometriosis
Endometriosis - complications
epithelial ovarian carcinoma
Female
histology
Humans
Middle Aged
Neoplasm Staging
Neoplasms, Glandular and Epithelial - blood
Neoplasms, Glandular and Epithelial - etiology
Neoplasms, Glandular and Epithelial - pathology
Obstetrics and Gynecology
Ovarian Neoplasms - blood
Ovarian Neoplasms - etiology
Ovarian Neoplasms - pathology
Retrospective Studies
Risk Factors
Young Adult
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Summary:Objectives To explore the differences between women with endometiosis associated ovarian cancer and typical epithelial ovarian cancer. Study Design The medical charts of total 226 patients with epithelial ovarian cancer treated at Peking Union Medical College Hospital between March 2011 and March 2012 were reviewed. Histology evaluation determined endometiosis associated ovarian cancer (n = 17) or nonendometiosis associated ovarian cancer (n = 209). Results Compared with nonendometiosis associated ovarian cancer, patients with endometiosis associated ovarian cancer were proved: (1) to be younger and more likely to be premenopausal at diagnosis of epithelial ovarian cancer ( P = .03 and .005, respectively); (2) to have lower preoperative serum level of Ca125 (mean: 122.9 vs 1377.5 U/mL, P < .001) and more likely to display normal Ca125 level ( P < .001); (3) to be identified at the earlier stage (stage I, P < .001); (4) to have completely different distribution of histological subtypes (significant overrepresentation of clear cell and endometrioid carcinoma). Conclusion As such, patients with endometiosis associated ovarian cancer differ from nonendometiosis associated ovarian cancer in many of their critical clinical and biologic characteristics.
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2012.12.004