A new turn-on fluorescent probe for selective detection of glutathione and cysteine in living cells

A fluorescent probe (N-(4-methyl-2-oxo-2H-chromen-7-yl)-2,4-dinitrobenzenesulfonamide), which exhibits high selectivity to glutathione and cysteine among amino acids including sulphur-containing methionine and metal ions, was synthesized. The experiments demonstrate that the fluorescent probe is a r...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2013-01, Vol.49 (41), p.4640-4642
Main Authors: Wei, Mingjie, Yin, Peng, Shen, Youming, Zhang, Lingli, Deng, Jianhui, Xue, Shanyan, Li, Haitao, Guo, Bin, Zhang, Youyu, Yao, Shouzhuo
Format: Article
Language:English
Subjects:
Coumarins - chemistry
Cysteine - analysis
Fluorescent Dyes - chemistry
Glutathione - analysis
HeLa Cells
Humans
Maleimides - chemistry
Microscopy, Fluorescence
Sulfonamides - chemistry
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Summary:A fluorescent probe (N-(4-methyl-2-oxo-2H-chromen-7-yl)-2,4-dinitrobenzenesulfonamide), which exhibits high selectivity to glutathione and cysteine among amino acids including sulphur-containing methionine and metal ions, was synthesized. The experiments demonstrate that the fluorescent probe is a reliable and specific probe for glutathione and cysteine in living cells.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc39045d