Expression analysis of tumor-related genes involved in critical regulatory pathways in schwannomas

Purpose Gene expression array analysis is providing key data on the potential candidate genes and biological pathways involved in schwannoma origin and development. In this way we performed expression array studies on tumor-related genes in schwannomas. Methods The GE Array Q Series HS-006 (SuperArr...

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Bibliographic Details
Published in:Clinical & translational oncology 2013-05, Vol.15 (5), p.409-411
Main Authors: Torres-Martín, Miguel, Martinez-Glez, Victor, Peña-Granero, Carolina, Lassaletta, Luis, Isla, Alberto, de Campos, Jose M., Pinto, Giovanny R., Burbano, Rommel R., Meléndez, Bárbara, Castresana, Javier S., Rey, Juan A.
Format: Article
Language:English
Subjects:
Brief Research Article
Gene Expression Profiling
Humans
Medicine
Medicine & Public Health
Neurilemmoma - genetics
Neurilemmoma - pathology
Oligonucleotide Array Sequence Analysis
Oncology
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Summary:Purpose Gene expression array analysis is providing key data on the potential candidate genes and biological pathways involved in schwannoma origin and development. In this way we performed expression array studies on tumor-related genes in schwannomas. Methods The GE Array Q Series HS-006 (SuperArray, Bethesda, MD, USA) was used to determine the expression levels of 96 genes corresponding to 6 primary biological regulatory pathways in a series of 23 schwannomas. Results We identified 15 genes down-regulated, primarily corresponding to signal transduction functions, and 26 genes up-regulated, most frequently involving cell adhesion functions. Conclusions In addition to the NF2 inactivation (considered as an early step), variations of other biological regulatory pathways might play a key role in schwannoma.
ISSN:1699-048X
1699-3055
DOI:10.1007/s12094-012-0937-5