β-Cyclodextrin conjugated magnetic, fluorescent silica core–shell nanoparticles for biomedical applications

• Published in: Carbohydrate polymers 2013-06, Vol.95 (1), p.449-457
• Main Authors: Badruddoza, Abu Zayed Md, Rahman, Md. Taifur, Ghosh, Sudipa, Hossain, Md. Zakir, Shi, Jizhong, Hidajat, Kus, Uddin, Mohammad Shahab
• Format: Article
• Language: English
• Subjects: Antineoplastic agents; Applied sciences; beta-cyclodextrin; beta-Cyclodextrins - administration & dosage; beta-Cyclodextrins - chemistry; biocompatibility; Biological and medical sciences; Cell Survival - drug effects; Cell targeting; Chemotherapy; Composites; Diagnostic Imaging; Drug Delivery Systems; drugs; Exact sciences and technology; Fluorescein-5-isothiocyanate; Fluorescence; fluorescent dyes; Fluorescent imaging; folic acid; Folic Acid - administration & dosage; Folic Acid - chemistry; Forms of application and semi-finished materials; HeLa Cells; Humans; Hydrophobic drug inclusion; hydrophobicity; image analysis; iron oxides; magnetism; Magnetite Nanoparticles - administration & dosage; Magnetite Nanoparticles - chemistry; MCF-7 Cells; Medical sciences; Multifunctional magnetic nanoparticles; nanocomposites; nanoparticles; Oleic Acid - chemistry; Pharmacology. Drug treatments; Polymer industry, paints, wood; silica; Silicon Dioxide - administration & dosage; Silicon Dioxide - chemistry; Technology of polymers; Tretinoin - chemistry; β-Cyclodextrin
• ISSN: 0144-8617; 1879-1344
• DOI: 10.1016/j.carbpol.2013.02.046

► Synthesis of β-CD conjugated magnetic, fluorescent silica core–shell nanoparticles. ► Multiple functionalities: magnetism, fluorescence, cell-targeting and drug delivery. ► β-CD moiety grafted on particle surface can act as a water-insoluble drug carrier. ► Applications in simultaneous bioimaging, cell-targeting and hydrophobic drug delivery. ► These NPs has shown potentials as a theranostic candidate in biomedical fields. We present synthesis of highly uniform magnetic nanocomposite material possessing an assortment of important functionalities: magnetism, luminescence, cell-targeting, and hydrophobic drug delivery. Magnetic particle Fe3O4 is encapsulated within a shell of SiO2 that ensures biocompatibility of the nanocomposite as well as act as a host for fluorescent dye (FITC), cancer-targeting ligand (folic acid), and a hydrophobic drug storage-delivering vehicle (β-cyclodextrin). Our preliminary results suggest that such core–shell nanocomposite can be a smart theranostic candidate for simultaneous fluorescence imaging, magnetic manipulation, cancer cell-targeting and hydrophobic drug delivery.