Photoresponsive Cross-linked Polymeric Particles for Phototriggered Burst Release

We synthesized a series of cross‐linked photoresponsive polymeric particles with photolabile monomers and cross‐linkers through miniemulsion polymerization. These particles are quite stable in dark, while light irradiation caused the breakage of particles and the efficient release of encapsulated co...

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Bibliographic Details
Published in:Photochemistry and photobiology 2013-05, Vol.89 (3), p.552-559
Main Authors: Wang, Zhen, Yu, Lili, Lv, Cong, Wang, Peng, Chen, Yedong, Tang, Xinjing
Format: Article
Language:English
Subjects:
Animals
Biological Transport
Cell Line
Cell Survival - drug effects
Emulsions
Ethanol - analogs & derivatives
Ethanol - chemistry
Fluoresceins
Fluorescence
Fluorescent Dyes
Macrophages - cytology
Macrophages - drug effects
Macrophages - metabolism
Methacrylates - chemical synthesis
Methacrylates - pharmacology
Mice
Microscopy
Microscopy, Electron, Scanning
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Nitrobenzenes - chemistry
Oxazines
Particle Size
Polymerization
Polymers
Spectrometry, Fluorescence
Spectrum analysis
Ultraviolet radiation
Ultraviolet Rays
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Summary:We synthesized a series of cross‐linked photoresponsive polymeric particles with photolabile monomers and cross‐linkers through miniemulsion polymerization. These particles are quite stable in dark, while light irradiation caused the breakage of particles and the efficient release of encapsulated contents up to 95% based on Nile red fluorescence. Photoswitches of particle systems were confirmed by fluorescence spectroscopy, SEM and colorimetry. Particle uptake and triggered release in RAW264.7 cells were confirmed by fluorescein diacetate loaded particles. Crosslinked photoresponsive polymeric nanoparticles encapsulated with target substances were synthesized with cross‐linkers and photolabile monomers through miniemulsion polymerization. These nanoparticles are quite stable in dark, while light irradiation triggered the burst release of trapped targets in both aqueous solutions and cells.
ISSN:0031-8655
1751-1097
DOI:10.1111/php.12038