Favorable Changes in Serum Estrogens and Other Biologic Factors After Weight Loss in Breast Cancer Survivors Who are Overweight or Obese

Micro-Abstract Blood samples and data from breast cancer survivors who were overweight and/or obese (n = 220) in a weight loss study were analyzed to assess effects of weight loss on hormones and biologic factors. Weight loss was associated with decreased insulin and leptin, and increased sex hormon...

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Bibliographic Details
Published in:Clinical breast cancer 2013-06, Vol.13 (3), p.188-195
Main Authors: Rock, Cheryl L, Pande, Chetna, Flatt, Shirley W, Ying, Carl, Pakiz, Bilge, Parker, Barbara A, Williams, Kathryn, Bardwell, Wayne A, Heath, Dennis D, Nichols, Jeanne F
Format: Article
Language:English
Subjects:
Aged
Biomarkers - blood
Breast Neoplasms - blood
Breast Neoplasms - complications
Estrogens - blood
Female
Hematology, Oncology and Palliative Medicine
Hormones
Humans
Insulin
Insulin - blood
Leptin
Leptin - blood
Middle Aged
Obesity
Obstetrics and Gynecology
Overweight - blood
Overweight - complications
Overweight - therapy
Sex Hormone-Binding Globulin - analysis
Weight Loss
Weight reduction
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Summary:Micro-Abstract Blood samples and data from breast cancer survivors who were overweight and/or obese (n = 220) in a weight loss study were analyzed to assess effects of weight loss on hormones and biologic factors. Weight loss was associated with decreased insulin and leptin, and increased sex hormone binding globulin, and reduced bioavailable estradiol in postmenopausal women. These changes suggested improved prognosis with weight reduction.
ISSN:1526-8209
1938-0666
DOI:10.1016/j.clbc.2012.12.002