The role of ADAM17 in metabolic inflammation

The TNF-alpha Converting Enzyme (TACE), also called ADAM17 (A Disintegrin and A Metalloproteinase 17) is a type I transmembrane metalloproteinase involved in the shedding of the extracellular domain of several transmembrane proteins such as cytokines, growth factors, receptors and adhesion molecules...

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Bibliographic Details
Published in:Atherosclerosis 2013-05, Vol.228 (1), p.12-17
Main Authors: Menghini, Rossella, Fiorentino, Loredana, Casagrande, Viviana, Lauro, Renato, Federici, Massimo
Format: Article
Language:English
Subjects:
ADAM Proteins - immunology
ADAM Proteins - metabolism
ADAM17 Protein
adhesion
adipose tissue
atherosclerosis
Atherosclerosis - immunology
Atherosclerosis - metabolism
Cardiovascular
diabetes
growth factors
Humans
Inflammation
Insulin resistance
Insulin Resistance - immunology
Macrophages
metabolism
Metalloproteinase
Obesity
Obesity - immunology
Obesity - metabolism
proteolysis
receptors
Steatosis
transmembrane proteins
tumor necrosis factor-alpha
Vasculitis - immunology
Vasculitis - metabolism
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Summary:The TNF-alpha Converting Enzyme (TACE), also called ADAM17 (A Disintegrin and A Metalloproteinase 17) is a type I transmembrane metalloproteinase involved in the shedding of the extracellular domain of several transmembrane proteins such as cytokines, growth factors, receptors and adhesion molecules. Some of these proteolytic events are part of cleavage cascades known as Regulated Intramembrane Proteolysis and lead to intracellular signaling. Evidence is provided that ADAM17 plays a role in atherosclerosis, in adipose tissue metabolism, insulin resistance and diabetes. The multitude of substrates cleaved by ADAM17 makes this enzyme an attractive candidate to study its role in inflammatory disorders. This review is focused on effects of ADAM17 in major metabolic tissues.
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2013.01.024