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The role of ADAM17 in metabolic inflammation
The TNF-alpha Converting Enzyme (TACE), also called ADAM17 (A Disintegrin and A Metalloproteinase 17) is a type I transmembrane metalloproteinase involved in the shedding of the extracellular domain of several transmembrane proteins such as cytokines, growth factors, receptors and adhesion molecules...
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| Published in: | Atherosclerosis 2013-05, Vol.228 (1), p.12-17 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c589t-63833df3948540d02b83d9d8918b2036a3237a2e33038516e2a0dd104365f7c93 |
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| cites | cdi_FETCH-LOGICAL-c589t-63833df3948540d02b83d9d8918b2036a3237a2e33038516e2a0dd104365f7c93 |
| container_end_page | 17 |
| container_issue | 1 |
| container_start_page | 12 |
| container_title | Atherosclerosis |
| container_volume | 228 |
| creator | Menghini, Rossella Fiorentino, Loredana Casagrande, Viviana Lauro, Renato Federici, Massimo |
| description | The TNF-alpha Converting Enzyme (TACE), also called ADAM17 (A Disintegrin and A Metalloproteinase 17) is a type I transmembrane metalloproteinase involved in the shedding of the extracellular domain of several transmembrane proteins such as cytokines, growth factors, receptors and adhesion molecules. Some of these proteolytic events are part of cleavage cascades known as Regulated Intramembrane Proteolysis and lead to intracellular signaling. Evidence is provided that ADAM17 plays a role in atherosclerosis, in adipose tissue metabolism, insulin resistance and diabetes. The multitude of substrates cleaved by ADAM17 makes this enzyme an attractive candidate to study its role in inflammatory disorders. This review is focused on effects of ADAM17 in major metabolic tissues. |
| doi_str_mv | 10.1016/j.atherosclerosis.2013.01.024 |
| format | article |
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Some of these proteolytic events are part of cleavage cascades known as Regulated Intramembrane Proteolysis and lead to intracellular signaling. Evidence is provided that ADAM17 plays a role in atherosclerosis, in adipose tissue metabolism, insulin resistance and diabetes. The multitude of substrates cleaved by ADAM17 makes this enzyme an attractive candidate to study its role in inflammatory disorders. 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This review is focused on effects of ADAM17 in major metabolic tissues.</description><subject>ADAM Proteins - immunology</subject><subject>ADAM Proteins - metabolism</subject><subject>ADAM17 Protein</subject><subject>adhesion</subject><subject>adipose tissue</subject><subject>atherosclerosis</subject><subject>Atherosclerosis - immunology</subject><subject>Atherosclerosis - metabolism</subject><subject>Cardiovascular</subject><subject>diabetes</subject><subject>growth factors</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Insulin resistance</subject><subject>Insulin Resistance - immunology</subject><subject>Macrophages</subject><subject>metabolism</subject><subject>Metalloproteinase</subject><subject>Obesity</subject><subject>Obesity - immunology</subject><subject>Obesity - metabolism</subject><subject>proteolysis</subject><subject>receptors</subject><subject>Steatosis</subject><subject>transmembrane proteins</subject><subject>tumor necrosis factor-alpha</subject><subject>Vasculitis - immunology</subject><subject>Vasculitis - metabolism</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqNkU1v1DAQhi0EokvhL0AuSBxImPHkwz6AtCpQkIo4tD1bXmdCvSRxsbNI_fc42sKhJy7-kJ53ZvSMEK8RKgRs3-0ru9xwDMmN6-lTJQGpAqxA1o_EBlWnS6xV_VhsACSWGhs4Ec9S2gNA3aF6Kk4kkcpPvRFvr264iGHkIgzF9uP2G3aFn4uJF7sLo3f5M4x2muziw_xcPBnsmPjF_X0qrj9_ujr7Ul58P_96tr0oXaP0UrakiPqBdK2aGnqQO0W97pVGtZNArSVJnZVMBKQabFla6HuEmtpm6JymU_HmWPc2hl8HTouZfHI8jnbmcEgGqe5k07b1ir4_oi7LSJEHcxv9ZOOdQTCrMLM3D4SZVZgBNFlYzr-8b3XYTdz_S_81lIFXR2CwwdgfMeevL3OFZrWpoe0ycX4kOCv57Tma5DzPjnsf2S2mD_6_h_nwoJIb_eydHX_yHad9OMQ5ezdokjRgLtf9rutFysO0oOkPc-SgQw</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Menghini, Rossella</creator><creator>Fiorentino, Loredana</creator><creator>Casagrande, Viviana</creator><creator>Lauro, Renato</creator><creator>Federici, Massimo</creator><general>Elsevier Ireland Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130501</creationdate><title>The role of ADAM17 in metabolic inflammation</title><author>Menghini, Rossella ; 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| ispartof | Atherosclerosis, 2013-05, Vol.228 (1), p.12-17 |
| issn | 0021-9150 1879-1484 |
| language | eng |
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| source | ScienceDirect Freedom Collection |
| subjects | ADAM Proteins - immunology ADAM Proteins - metabolism ADAM17 Protein adhesion adipose tissue atherosclerosis Atherosclerosis - immunology Atherosclerosis - metabolism Cardiovascular diabetes growth factors Humans Inflammation Insulin resistance Insulin Resistance - immunology Macrophages metabolism Metalloproteinase Obesity Obesity - immunology Obesity - metabolism proteolysis receptors Steatosis transmembrane proteins tumor necrosis factor-alpha Vasculitis - immunology Vasculitis - metabolism |
| title | The role of ADAM17 in metabolic inflammation |
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