Factors That May Influence Estimated Glomerular Filtration Rate in Patients With Excellent Graft Function 10 Years Posttransplant

• Published in: Transplantation proceedings 2013-04, Vol.45 (3), p.1060-1062
• Main Authors: Guerra, J, Raimundo, M, Teixeira, C, Santana, A, Cortesão, A, Gomes da Costa, A
• Format: Article
• Language: English
• Subjects: Adult; Female; Glomerular Filtration Rate; Graft Survival; Humans; Kidney - physiopathology; Kidney Transplantation; Male; Middle Aged; Retrospective Studies; Surgery
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2013.03.003

Abstract Background Donor age, cold ischemia time, delayed graft function (DGF), prior sensitization, HLA mismatches, acute rejection episodes, glomerular disease and viral nephropathy are some factors that shorten graft survival. Patients with excellent graft function at 10 years posttransplant have probably successfully overcome these detrimental factors. The effect of initial functional renal mass is probably associated with this outcome. The objective of the present study was to identify factors that show predictive value for the population of patients with excellent graft function at 10 years posttransplantation. Patients and methods This retrospective observational study included 117 patients transplanted from deceased donors. They all presented glomerular filtration rates (GFR) ≥ 40 mL/min. They were stratified as group I ( n = 56) estimated GFR ≥ 40 10 mL/min between the 1st and the 10th year correlated significantly with donor age ( P = .04). The deterioration of graft function was greater among group I than group II (6.7 vs 0.23 mL/min; P = .007). Conclusion Donor age was the most significant predictive factor for graft function at 10 years.