A Case Series of De Novo Inflammatory Bowel Disease After Kidney Transplantation

Abstract Diarrhea, which is common after transplantation, may be due to infections and immunosuppressive therapy. Inflammatory bowel disease (IBD) de novo or as an exacerbation of pre-existent disease is a rare complication after kidney transplantation with pre-existing disease having a less aggress...

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Bibliographic Details
Published in:Transplantation proceedings 2013-04, Vol.45 (3), p.1084-1087
Main Authors: Azevedo, P, Freitas, C, Aguiar, P, Silva, H, Santos, T, Farrajota, P, Almeida, M, Pedroso, S, Martins, L.S, Dias, L, Vizcaíno, R, Henriques, A. Castro, Cabrita, A
Format: Article
Language:English
Subjects:
Adult
Female
Humans
Immunosuppressive Agents - adverse effects
Inflammatory Bowel Diseases - chemically induced
Kidney Transplantation
Male
Middle Aged
Surgery
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Summary:Abstract Diarrhea, which is common after transplantation, may be due to infections and immunosuppressive therapy. Inflammatory bowel disease (IBD) de novo or as an exacerbation of pre-existent disease is a rare complication after kidney transplantation with pre-existing disease having a less aggressive clinical course than the de novo disease. Cytomegalovirus mismatch, prescription of tacrolimus instead of cyclosporine or mycophenolate mofetil rather than azathioprine as well as low-dose corticosteroid treatments have been linked to an increased incidence of IBD. This series of renal transplant recipients with de novo IBD showed a higher incidence and more aggressive course than that previously described, possibly related to increased use of tacrolimus with minimization of steroids.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2013.03.008