A comparative chemical-biological evaluation of titanium(IV) complexes with a salan or cyclopentadienyl ligand

Titanium(IV) complexes with a salan or cyclopentadienyl ligand showed different biological behaviour concerning binding to biomolecules, cellular accumulation and intracellular distribution. Binding efficacy as well as trafficking on the cellular level are crucial parameters for their biological eff...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2013-05, Vol.49 (42), p.4785-4787
Main Authors: Schur, Julia, Manna, Cesar M, Deally, Anthony, Köster, Reinhard W, Tacke, Matthias, Tshuva, Edit Y, Ott, Ingo
Format: Article
Language:English
Subjects:
Albumins - metabolism
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Cell Survival - drug effects
Coordination Complexes - chemistry
Coordination Complexes - pharmacology
DNA - metabolism
Embryo, Nonmammalian - drug effects
HT29 Cells
Humans
Ligands
MCF-7 Cells
Organometallic Compounds - chemistry
Organometallic Compounds - pharmacology
Titanium - chemistry
Titanium - pharmacology
Zebrafish
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Summary:Titanium(IV) complexes with a salan or cyclopentadienyl ligand showed different biological behaviour concerning binding to biomolecules, cellular accumulation and intracellular distribution. Binding efficacy as well as trafficking on the cellular level are crucial parameters for their biological effects.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc38604j