Hypoiodite mediated synthesis of isoxazolines from aldoximes and alkenes using catalytic KI and Oxone as the terminal oxidant

Isoxazolines can be efficiently synthesized in good yields via a hypoiodite mediated catalytic oxidative cyclization of aldoximes and alkenes. This reaction involves active iodine species generated in situ from catalytic amounts of KI and Oxone.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2013-01, Vol.49 (42), p.4800-4802
Main Authors: Yoshimura, Akira, Zhu, Chenjie, Middleton, Kyle R, Todora, Anthony D, Kastern, Brent J, Maskaev, Andrey V, Zhdankin, Viktor V
Format: Article
Language:English
Subjects:
Alkenes - chemistry
Catalysis
Cyclization
Iodine Compounds - chemistry
Isoxazoles - chemistry
Oxidants - chemistry
Oximes - chemistry
Potassium Iodide - chemistry
Sulfuric Acids - chemistry
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Description
Summary:Isoxazolines can be efficiently synthesized in good yields via a hypoiodite mediated catalytic oxidative cyclization of aldoximes and alkenes. This reaction involves active iodine species generated in situ from catalytic amounts of KI and Oxone.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc41164h